| 盐酸芦氟沙星凝胶剂的研制 |
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| 引用本文： | 刘福,吴功柱.盐酸芦氟沙星凝胶剂的研制[J].中国药房,2003,14(11):665-666. |
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| 作者姓名： | 刘福 吴功柱 |
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| 作者单位： | 川北医学院附属医院药剂科,南充市,637000 |
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| 摘 要： | 目的 :制备盐酸芦氟沙星凝胶 ,并建立质量控制方法。方法 :以卡波姆940为基质制备凝胶 ,采用紫外分光光度法测定盐酸芦氟沙星含量 ,并考察其稳定性。结果 :盐酸芦氟沙星线性范围为2～10μg/ml(r=0 9999) ,平均回收率为99 52 % ,RSD=0 38 % (n=6) ;凝胶稳定性良好。结论 :该凝胶制备工艺可行 ,性质稳定
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| 关 键 词： | 盐酸芦氟沙星 凝胶剂 制备 质量控制 |
| 文章编号： | 1001-0408(2003)11-0665-02 |
| 修稿时间： | 2002年12月25 |
Preparation of Rufloxacin Hydrochloride Gel |
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| LIU Fu,WU Gongzhu.Preparation of Rufloxacin Hydrochloride Gel[J].China Pharmacy,2003,14(11):665-666. |
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| Authors: | LIU Fu WU Gongzhu |
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| Abstract: | OBJECTIVE:To prepare rufloxacin hydrochloride gel and establish a quality control method of the gel METHODS:Carbopol940 was used as the gel base,the content of rufloxacin hydrochloride was determined with UV-spectrophotometry and the stability test was performed RESULTS:There was a good linearity of calibration curve of rufloxacin hydrochloride in range 2～10μg/ml,r=0 9 999,the average recovery was 99 53%,RSD was 0 38%(n=6) The gel was stable CONCLUSION:The design of the gel formulation is reasonable The gel can be prepared feasibly and is stable in quality,convenient in use |
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| Keywords: | rufloxacin hydrochloride gel preparation quality control |
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