| 肉苁蓉总苷对四氯化碳损伤小鼠肝脏能量代谢的影响 |
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| 引用本文： | 罗慧英,黄亚红,朱丽娟. 肉苁蓉总苷对四氯化碳损伤小鼠肝脏能量代谢的影响[J]. 甘肃中医学院学报, 2014, 0(4): 4-6 |
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| 作者姓名： | 罗慧英 黄亚红 朱丽娟 |
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| 作者单位： | 甘肃中医学院药理教研室,甘肃省中药药理与毒理学省级重点实验室,甘肃兰州730000 |
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| 基金项目： | 甘肃中医学院引进人才科研启动基金项目（项目编号：1） |
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| 摘 要： | 目的观察肉苁蓉总苷对四氯化碳（CCl4）损伤小鼠肝脏能量代谢的影响。方法通过建立模型评价肉苁蓉总苷对CCl4损伤小鼠肝脏乳酸（LD）、乳酸脱氢酶（LDH）及Na^＋-K^＋-ATPase和Ca^2＋ ATPase的影响。结果通过CCl4损伤后，小鼠肝细胞匀浆中LD含量升高，LDH，Na^＋-K^＋-ATPase及Ca^2＋ATPase活性降低；肉苁蓉总苷能明显降低小鼠肝细胞匀浆中LD含量，增加LDH，Na^＋-K^＋-ATPase及Ca^2＋ATPase活性。结论肉苁蓉总苷能显著改善CCl4损伤小鼠肝脏的能量代谢。
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| 关 键 词： | 肉苁蓉总苷 四氯化碳 能量代谢 |
The effect of glycosides of cistanches on hepatic energy metabolism in mice injured by CCl4 |
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| Luo Huiying,Huang Yahong,Zhu Lijuan. The effect of glycosides of cistanches on hepatic energy metabolism in mice injured by CCl4[J]. Journal of Gansu College of Traditional Chinese Medicine, 2014, 0(4): 4-6 |
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| Authors: | Luo Huiying Huang Yahong Zhu Lijuan |
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| Affiliation: | ( Gansu College of TCM, Gansu Key Laboratory for Pharmacology and Toxicology of Traditional Chinese Drugs, Lanzhou ,730000, China) |
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| Abstract: | Objective To investigate lism in mice injured by CC14. Methods the effect of glycosides of cistanches （GCs） on hepatic energy metabo- We built injured model and compared the content of LD, LDH, Na^＋-K^＋- ATPase and Ca^2＋ ATPase, then evaluated the effect of GCs on hepatic energy metabolism in mice. Results GCs can obviously reduce the LD content ; stimulate the activities of LDH, Na^＋-K^＋-ATPase and Ca^2＋ ATPase in mice in- jured by CCl4. Conclusion GCs can improve the hepatic energy metabolism in mice injured by CCl4. |
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| Keywords: | glycosides of cistanches CCl4 energy metabolism |
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