中药复方对抗雷公藤多苷毒性的研究Ⅲ对雷公藤多苷抗炎作用的影响

以瓜菱、石斛、白芍、川芎、生地、元参、牛膝、五味子、菟子、枸杞子、车前子、覆盆子、益母草、泽兰、麦冬、当归组成的中药复方，其水提剂１１．２７，５．６４，２．８２ｇ／ｋｇ与等量雷公藤多苷组成复方制剂级动物ｉｇ。小剂量复方中药＋雷公藤多苷组对小鼠急性、慢必琰症及大鼠急性和免疫炎症均有明显的抑制作用，且该作用优于等剂量的雷公藤多苷。中药复方剂量过大可拮抗雷公藤多苷的抗炎作用。

Studies on Compounded TCM to Antagonize the Side Effects of Multi-glycosides of Wilford Threewingnut (Tripterygium wilfordii) II .Effect on the Anti-inflammatory Action of Multi-}Ivcosides of T. wilfordii

Water decoction of compositus traditional Chinese medicine, composed of Fructus Trichosanthis, Herba Dendrobii, Radix Paeoniae Alba, etc., at doses of 11. 27, 5. 64, 2. 82 g/kg, mixed with the same doses of multi--glycosides of Tripterygium wilfordii Hook. f. for oral administration to animal models. 2. 82 g/kg and same dose of multi--glycosides of T. wilfordii can resist apprently acute and chronic inflammation of mice as well as acute and immunization inflammation of rats, superior to the same dosages of multi-glycosides of T. wilfordii alone. Too large doses of compositus traditional Chinese medicine can antagonize the antiinflammatory action of multi-glycosides of T. wilfordii.