间日疟原虫氯喹抗性研究进展李

疟疾仍然是一个严重危害人类健康的公共卫生问题， 尤其多见于发展中国家。随着认识的深入， 间日疟也获得 越来越多的重视。有效的药物治疗是控制疟疾甚至消除疟疾的基石， 近年来已有越来越多的间日疟原虫氯喹抗性报道， 间日疟原虫氯喹抗性已成为间日疟防治中一个备受关注的问题。本文就间日疟原虫氯喹抗性的分布现状、 体内外检测方 法和分子检测标志物研究进展进行初步总结。

Research progress on Plasmodium vivax chloroquine resistance

Malaria remains a serious public health problem,especially in developing countries. With the deepening of the un-derstanding of vivax malaria,Plasmodium vivax is also attracting more and more attention. An effective drug treatment is the foun-dation of controlling or even eliminating malaria. In recent years,more and more reports of chloroquine-resistance Plasmodium vivax have been reported. Plasmodium vivax chloroquine resistance has been a focus problem in vivax malaria prevention and treat-ment. In this paper,the research progress on distribution situation,detection methods and molecular markers of Plasmodium vivax chloroquine resistance is summarized.