孕早期妇女弓形虫感染对妊娠结局的影响

目的 目的 探讨孕早期妇女弓形虫感染对妊娠结局的影响。方法 方法 采用酶联免疫吸附试验检测2 993例孕妇外周血中弓形虫IgM和IgG抗体， 将感染者分为急性感染组、 既往感染组、 活动性感染组， 并从非感染者中随机抽取200 名孕妇作为对照组， 对4组进行随访， 观察比较4组的妊娠结局。结果 结果 共检测出弓形虫感染者286例， 总感染率为9.56%（286/2 993）， 其中急性感染43例、 既往感染156例、 活动性感染87例； 以上3组及对照组不良妊娠结局发生率分别为13.95% （6/43）、 1.92% （3/156）、 5.75% （5/87） 和1.50% （3/200）。急性感染组和活动性感染组不良妊娠结局发生率与对照组比较， 差异均有统计学意义 （P均＜0.05）； 既往感染组与对照组比较， 差异无统计学意义 （P＞0.05）。结论 结论 弓形虫急性感染和活动性感染与孕早期妇女不良妊娠结局密切相关， 应将弓形虫IgM抗体检测作为育龄妇女孕前常规检查项目。

Impact of Toxoplasma gondii infection on pregnancy outcomes in early pregnant women

Objective To explore the impact of Toxoplasma gondii infection on pregnancy outcomes in early pregnancy wom-en. Methods Toxoplasma gondii IgM and IgG antibodies in the peripheral blood of 2 993 early pregnant women were detected by using enzyme-linked immunosorbent assay（ELISA）. According to the test results,the infected ones were divided into an acute in-fection group,a previous infection group,and an active infection group,and 200 pregnant women without Toxoplasma infection were randomly chosen as a control group,and the pregnancy outcomes of the four groups were followed up and the results were compared. Results There were 286 women infected with Toxoplasma gondii,with the infection rate of 9.56%（286/2 993）,in which 43 cases were diagnosed as acute infection,156 were previous cases,and the other 87 were active infection ones. The inci-dences of adverse pregnancy outcomes in the above 3 groups and the control group were 13.95%（6/43）,1.92%（3/156）,5.75%（5/87）and 1.50%（3/200）,respectively. The incidences of adverse pregnancy outcomes in the acute infection group and active in-fection group were both higher than that in the control group,the differences were statistically significant（both P＆lt;0.05）,while there was no significant difference between the previous infection group and control group（P＆gt;0.05）. Conclusion Acute and ac-tive Toxoplasma gondii infections are closely associated with the occurrence of adverse pregnancy outcomes in early pregnant wom-en;therefore,Toxoplasma gondii IgM antibody should be included in the routine inspection items of the pre-pregnancy physical examination for child-bearing age women.