Capture of recombinant ricin A chain by a bispecific anti-RTA: anti-CEA monoclonal antibody pre-targeted to a human gastric carcinoma xenograft in nude mice |
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| Authors: | M. V. Pimm R. A. Robins R. W. Baldwin |
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| Affiliation: | (1) Cancer Research Campaign Laboratories, University of Nottingham, NG7 2RD Nottingham, UK |
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| Abstract: | Summary A bispecific antibody against carcinoembryonic antigen (CEA) and ricin A chain has been shown to localise in a CEA-producing human tumour xenograft. When labelled recombinant ricin A chain was subsequently injected there was uptake into tumours, indicating that this bispecific antibody can capture or carry toxin into tumour deposits.Abbreviations CEA carcinoembryonic antigen - r-RTA recombinant ricin toxin A chain |
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| Keywords: | Ricin A chain Bispecific antibody CEA Carcinoma xenograft |
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