中药诱导骨髓间充质干细胞的定向分化：研究与进展

BACKGROUND: In recent years, in-depth studies that single Chinese herbs or extracts, compound traditional Chinese medicine and medicated serum are used to regulate the directional differentiation of bone marrow mesenchymal stem cells into myofibroblasts, chondrocytes, osteoblasts, myocardial cells and nerve cells, which have become a highlight in the tissue engineering research.OBJECTIVE: To review the latest progress in the directional differentiation of bone marrow mesenchymal stem cells induced by Chinese herbs or their extracts.METHODS: The first author searched the CNKI, Wanfang and PubMed databases using the keywords of “Chinese herb, directional differentiation, mesenchymal stem cells” in Chinese and English, respectively, to retrieve relevant articles published from January 2010 to January 2016. Repetitive articles or those with no originality were eliminated. Totally 99 articles were searched initially, and then 43 articles were included in result analysis.RESULTS AND CONCLUSION: As the strongest seed cells in the bone differentiation system, bone marrow mesenchymal stem cells have a wide range of directional differentiation potential, and highlight the important value in combination with Chinese herbs for clinical treatment of various refractory diseases, especially for treatment of metabolic bone diseases, bone defects, nonunion and delayed union, which is not only conducive to in-depth, multi-angle studies on effects and mechanisms of Chinese herbs, but also to clinical treatment of various refractory diseases using bone marrow mesenchymal stem cells.   中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Directional differentiation of bone marrow mesenchymal stem cell induced by traditional Chinese Medicine