转化生长因子β信号与肌肉调控 |
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作者姓名: | 王今越 |
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作者单位: | 佛山科学技术学院,广东省佛山市 528000 |
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基金项目: | 广东省高校优秀青年创新人才培养计划资助项目(2012WYM_0126);广东高校校级特色创新项目(2015xts14) |
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摘 要: | BACKGROUND: Transforming growth factor-β signaling widely existing in cells mediates cell growth, proliferation, migration, differentiation, and apoptosis. The activation of transforming growth factor-β signaling can result in muscular dystrophy. However, there have been some contradictions regarding the effects of the transforming growth factor-β signaling on muscular dystrophy.
OBJECTIVE: To summarize the latest progress in the effects of the transforming growth factor-β signaling on muscle mass and function regulation to provide the solutions for the treatment of muscular dystrophy.
METHODS: A computer-based online search was conducted in PubMed and Wanfang databases from 2005 to 2015 to screen the relevant literatures using Chinese and English key words “transforming growth factor-β, muscle, regulation mechanism, treatment”. A total of 102 literatures were retrieved, and 22 eligible literatures were included, summarized, and analyzed.
RESULTS AND CONCLUSION: The activation of transforming growth factor-β signaling as a common cause of most muscle disorders promotes the activation of muscle satellite cells, differentiation of myocytes, myoblast infusion, the expression of muscle-specific proteins, and the inhibition of collagen synthesis, which facilitates muscular fibrosis and scar formation. Transforming growth factor-β signaling is involved in Duchenne muscular dystrophy, spinal scoliosis, type I diabetes induced skeletal muscle regenerative disorders, myocardial and cardiac remodeling. The inhibition of transforming growth factor-β signaling may result in incomplete muscle recovery.
中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程
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关 键 词: | 组织构建 组织工程 转化生长因子β 机制 线粒体 肌肉 |
收稿时间: | 2016-06-05 |
Transforming growth factor-beta and muscle regulation |
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Authors: | Wang Jin-yue |
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Institution: | Foshan University, Foshan 528000, Guangdong Province, China |
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Abstract: | |
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Keywords: | Transforming Growth Factors Signal Transduction Muscular Disorders Atrophic |
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