骨诱导性磷酸钙陶瓷材料修复牙槽突裂 |
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作者姓名: | 陈浩东 姚金凤 梁志刚 |
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作者单位: | 广州医科大学,广东省广州市 510000;深圳市第二人民医院,广东省深圳市 518000 |
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基金项目: | 深圳市科技创新委员会基础研究计划(JCYJ20130401111426275,JCYJ20140414170821224) |
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摘 要: |
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关 键 词: | 生物材料 口腔生物材料 磷酸钙陶瓷 牙槽突裂 骨诱导 人工骨 生物矿化 |
收稿时间: | 2016-08-29 |
Osteoinductive calcium phosphate ceramics repair alveolar cleft defects |
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Authors: | Chen Hao-dong Yao Jin-feng Liang Zhi-gang |
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Institution: | Guangzhou Medical University, Guangzhou 510000, Guangdong Province, China; Shenzhen Second People’s Hospital, Shenzhen 518000, Guangdong Province, China |
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Abstract: | BACKGROUND: In our previous studies, we had prepared calcium phosphate ceramics with better ectopic osteogenesis.
OBJECTIVE: To explore the effect of novel osteoinductive calcium phosphate ceramics in the repairing of alveolar cleft.
METHODS: Bilaterl alveolar defects were created in nine immature beagles. Three months later, osteoinductive calcium phosphate ceramics with high modular surface (experimental group) and smooth surface (control group) were randomly implanted in each side of the defect. Meanwhile, the corresponding material was implanted into the thigh muscle. New bone formation in the implanted region, osteogenesis in the implanted region and muscle, and respair results were respectively observed by fluorescence microscope, light microscope and CT at 4, 8 and 12 weeks after implantation.
RESULTS AND CONCLUSION: (1) Fluorescence microscope observation: A circular permutation of red, yellow and green fluorescent strip could be observed in both two groups. (2) Light microscope observation: At 12 weeks after implantation, in the experimental group, the bone reconstruction was obvious, the implant material was decomposed gradually, the gap was filled with a large number of mature bone that combined with the rest material closely, and numerous Haversian canals appeared; the control group was similar but slightly inferior to the experimental group in the quality of new bone. The experimental group material successfully induced heterotopic osteogenesis in muscle, while the control did not. (3) CT examination: The two group materials restored the appearance and continuity of the alveolar ridge, and made no effect on the eruption of permanent teeth in both sides of the defect. To conclude, our findings suggest that the novel osteoinductive calcium phosphate ceramic exhibits advantages in alveolar cleft repair with earlier osteogenesis activation, faster osteogenesis rate and more bone formation than those traditional materials. |
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Keywords: | Calcium Phosphates Dental Procelain Alveolar Process Tissue Engineering |
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