干细胞转化技术是干细胞基础和未来临床移植研究的基石

Stem cell conversion technology is a footstone for stem cell basic and clinical research in the future

BACKGROUND: Stem cell conversion technology has become an active area in the field of stem cell research, and it also has a tremendous boost on both the stem cell basic research and clinical study.OBJECTIVE: To review the research status and the current progress of stem cell conversion technology.METHODS: In the titles and summaries, the “stem cells, conversion, differentiation” in Chinese and English served as the search terms to search articles related to stem cells technology published from January 2000 to April 2015 in CNKI and PubMed databases. The latest articles or articles published on the authoritative journals  were preferred. Totally 121 articles were obtained after initial survey, and according to the inclusion criteria, 64 articles were selected for overview.RESULTS AND CONCLUSION: The progress of stem cells conversion technology has driven the development of the entire stem cell research, including modifying the ratio of culture medium, increasing specific inducers, proteins, enzymes or receptors, injecting specific genes, using new oxidizing agents, modifying culture microenvironment, culture under hypoxia, scaffold usage, applying transgenic technology, three-dimensional spherical culture or co-culture. Stem cell conversion technology will definitely increase the conversion rate of stem cells, which can bring hope for the treatment of refractory diseases.