有机磷中毒供肾移植的效果评价 |
| |
作者姓名: | 董建辉 李海滨 孙煦勇 秦 科 廖吉祥 李美思 黄晓诞 黄 晨 黄 莹 曹 嵩 高 照 李壮江 聂 峰 杨建均 |
| |
作者单位: | 解放军第三〇三医院移植医学研究院,广西移植医学重点实验室,解放军广州军区器官移植中心,广西移植医学工程技术研究中心,广西壮族自治区南宁市 530021 |
| |
基金项目: | 广西自然基金(2013GXNSFAA019253);广西科学研究与技术开发计划项目(桂科攻14124003-8),广西壮族自治区卫生与计生委员会课题(Z2015293) |
| |
摘 要: | BACKGROUND: Delayed graft function (DGF) occurs frequently in kidney transplants from donation after cardiac death if creatinine level is high in kidney recipients.
OBJECTIVE: To analyze the clinical effects of renal transplantation with kidneys from donors dying of cardiac death in organophosphate poisoning.
METHODS: Data were collected from kidney transplants from two donors dying of cardiac death in organophosphate poisoning. After some donor maintenance, donor organ were obtained and perfused with impulse type machine. Recipients were treated with intervention of immunity induction, anti-rejection drugs and infection prevention drugs during and after renal transplantation. Pathological data of donor kidney zero needle biopsy, DGF after kidney transplantation, complication rate (such as acute rejection), renal allograft recovery situation, the survival rate of recipients and kidney transplants were collected and analyzed.
RESULTS AND CONCLUSION: Needle biopsy results from four donor kidneys showed that glomerular morphology was normal, but there were edema and degeneration in kidney tubules in some degree. Donor DGF rate was 75% (3/4), acute rejection rate was 0% (0/4), perioperative period donor kidney and recipient survival rate were 100% (4/4). All recipients showed a good result of transplanted kidney, their creatinine and urea nitrogen were at low level, and had no proteinuria. One recipient died of severe pulmonary infection 4 months after surgery. For some organophosphate poisoning donors dying of cardiac death, donor kidney quality can be improved by suitable donor maintenance and high-quality donor kidney preservation using machine perfusion. Kidney transplants from donors dying of cardiac death in organophosphate poisoning who receive the maintenance of organ function may be a promising candidate for renal transplantation due to a severe lack of kidney donor sources.
中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程
|
关 键 词: | 组织构建 组织工程 有机磷中毒 脑死亡 器官捐献 肾移植 机械灌注 肾功能延迟恢复 广西壮族自治区自然科学基金 |
收稿时间: | 2016-04-25 |
Clinical effects of renal transplantation with kidneys from donors dying of organophosphate poisoning |
| |
Authors: | Dong Jian-hui Li Hai-bin Sun Xu-yong Qin Ke Liao Ji-xiang Li Mei-si Huang Xiao-dan Huang Chen Huang Ying Cao Song Gao Zhao Li Zhuang-jiang Nie Feng Yang Jian-jun |
| |
Institution: | Institute of Transplant Medicine, No. 303 Hospital of Chinese PLA; Guangxi Key Laboratory for Transplantation Medicine Guangxi, Department of Organ Transplantation in Guangzhou Military Region; Guangxi Transplantation Medicine Research Center of Engineering Technology, Nanning 530021, Guangxi Zhuang Autonomous Region, China |
| |
Abstract: | |
| |
Keywords: | Organ Transplantation Kidney Transplantation |
|
| 点击此处可从《》浏览原始摘要信息 |
| 点击此处可从《》下载免费的PDF全文 |