乳杆菌属和双歧杆菌属对成年人血脂水平影响的Meta

目的 评价乳杆菌属及双歧杆菌属对成年人血脂水平的影响。方法 计算机检索Pubmed、EMbase、Web of Science、Cochrane Library、中国学术期刊网络出版总库、万方医学数据库、维普中文科技期刊全文数据库。检索时间年限为建库至2016年1月。纳入标准为单纯使用乳杆菌属和（或）双歧杆菌属调节血脂的临床随机对照试验，研究对象年龄≥18岁，文献Jadad评分＞3分。提取资料后采用Revman 5.3软件进行Meta分析。结果 共纳入11篇文献，合计 871例研究对象。Meta分析结果显示，与对照组比较，应用乳杆菌属、双歧杆菌属可以显著降低血总胆固醇水平（WMD =-0.45 mmol/L，95%CI:-0.63 ~ -0.27 mmol/L，P＜0.001）和低密度脂蛋白胆固醇水平（WMD = -0.42 mmol/L，95%CI:-0.46 ~ -0.38 mmol/L，P＜0.001），差异有统计学意义。结论 乳杆菌属及双歧杆菌属对成年人血胆固醇代谢有一定积极影响。

Meta analysis of the influence of lactobacillus and bifidobacterium on blood lipid level in adults

Objective The study aimed to evaluate the influence of lactobacillus and bifidobacterium on blood lipid level in adults. Methods Relevant literatures published between the earliest available date to January of 2016 were retrieved from electronic databases, including Pubmed, EMbase, Web of Science, Cochrane Library, CNKI, WANFANG, and VIP. The inclusion criteria were clinical randomized controlled trials (RCT) involving regulation of blood lipid by using lactobacillus and/or/) bifidobacterium only. Age of the research subjects was no less than 18 years old. Jadad score of the articles was higher than 3. After data exaction, Revman 5.3 software was adopted to conduct a Meta analysis on the extracted data. Results A total of 11 articles containing 871 subjects were included. Meta analysis showed that as compared with control groups, the consumption of lactobacillus and bifidobacterium could significantly decrease total blood cholesterol level (WMD=-0.45 mmol/L, 95%CI: -0.63 to -0.27 mmol/L, P<0.001) and low-density lipoprotein cholesterol level (WMD=-0.42 mmol/L, 95%CI: -0.46 to -0.38 mmol/L, P<0.001); the differences were statistically significant. Conclusion Lactobacillus and bifidobacterium have positive influences on metabolism of blood cholesterol in adults.