智能水凝胶在骨类硬组织再生和修复中的应用

Application of intelligent hydrogels in bone regeneration and repair

BACKGROUND: Intelligent hydrogel as a new material is widely used in biological medicine, tissue engineering, memory element switch, biological enzyme immobilization and other related fields, and exhibits good biological characteristics. Intelligent hydrogels provide a new approach for regeneration and repair of bone and other hard tissues. OBJECTIVE: To summarize the latest developments of intelligent hydrogel in the biological medicine and tissue engineering in order to find out new methods for regeneration and repair of bone and other hard tissues.METHODS: A computer-based research of CNKI, PubMed and EBSCO-MEDLINE databases was performed to retrieve relevant literatures about the application of intelligent hydrogel in regeneration and repair of bone and other hard tissues published from 2000 to 2015. The keywords were “hydrogel, bone tissue engineering, bone defect, regeneration, repair” in Chinese and English, respectively.RESULTS AND CONCLUSION: Intelligent hydrogels are classified into pH-sensitive, temperature-sensitive, light-sensitive, multiple-sensitive and other sensitive hydrogels. In order to improve the mineralization ability of the hydrogel and construct the three-dimensional polymer scaffold of hydrogel, the main structure of the hydrogel materials can be mixed with various signal factors, thus achieving the multi-utility and multi-function of the material system, which will become the development trend of tissue engineering construction.