椎体成形结合抗骨质疏松治疗减少再骨折发生率 |
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作者姓名: | 杨富国 杨 波 尹 飚 黎双庆 杨逸禧 龚翼星 |
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作者单位: | 广州医科大学附属第三医院骨科,广东省广州市 510150 |
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基金项目: | 广东省科技计划项目(2014A020212355);广东省研究生教育创新计划项目-创新强校(B158035) |
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摘 要: | BACKGROUND: Currently, vertebral compression fractures are the most common osteoporotic fracture in postmenopausal women; however, incidence of refracture has aroused increasing attention due to a lack of standard treatment.
OBJECTIVE: To evaluate whether vertebroplasty combined with anti-osteoporosis treatment can reduce refracture rate following osteoporotic vertebral compressive fractures.
METHODS: Eighty-nine patients with osteoporotic vertebral compressive fractures undergoing vertebroplasty were divided into control group (n=38) and treatment group (n=51) after making an informed choice about treatment. Chest/lumbar X-ray and bone mineral density determinations were performed through outpatient or inpatient follow-up. The spinal stability, bone mineral density and refracture rate of patients in both groups were followed up.
RESULTS AND CONCLUSION: Seventy-eight patients achieved complete follow-up (ranged from 6-39 months, average 26.73 months). There was no significant difference in the spinal stability between both groups (P > 0.05), while rare bone trabecula was found in the control group. There was a significant difference in bone mineral density between both groups at postoperative 12, 24, and 36 months (P < 0.05). The refracture rate in the treatment group was significantly lower than that in the control group (P < 0.05). Our results indicate that anti-osteoporosis treatment can effectively reduce the incidence of refracture after vertebroplasty in patients with osteoporotic vertebral compressive fractures, and this study found satisfactory short- and medium-term clinical outcomes.
中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程
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关 键 词: | 组织构建 骨组织工程 骨质疏松症 骨质疏松性椎体压缩性骨折 椎体成形术 抗骨质疏松 再骨折 |
收稿时间: | 2016-05-24 |
Vertebroplasty combined with anti-osteoporosis treatment reduces refracture rate |
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Authors: | Yang Fu-guo Yang Bo Yin Biao Li Shuang-qing Yang Yi-xi Gong Yi-xing |
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Institution: | Department of Orthopedics, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China |
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Abstract: | |
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Keywords: | Fractures Compression Osteoporotic Fractures Vertebroplasty Tissue Engineering |
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