2型糖尿病周围神经病变患者骨密度的变化

目的: 分析2型糖尿病（T2DM）并发周围神经病变患者的骨密度变化。方法: 收集T2DM患者82例，分为并发糖尿病周围神经病变组（DPN组）41例和无糖尿病周围神经病变组（NDPN组）41例；另选同期健康体检者80例为对照组。采用双能X线吸收法（DEXA）测量所有受试者腰椎及髋部骨密度。结果： NDPN组股骨Ward′s三角区骨密度较对照组明显增高（P＜0.05），DPN组股骨Ward′s三角区骨密度较NDPN组明显降低（P＜0.05）；进一步按性别分层分析，上述变化仅存在于女性T2DM患者。3组间腰椎、股骨颈、髋部总体区骨密度差异无统计学意义（P＞0.05）。结论： 女性T2DM患者Ward′s三角区骨密度在并发周围神经病变前升高，在并发周围神经病变后降低；男性T2DM并发周围神经病变患者骨密度无明显变化。

Change of bone mineral density in type 2 diabetes mellituspatients complicated with peripheral neuropathy

Objective To analyze the change of bone mineral density(BMD) in type 2 diabetes mellitus(T2DM) patients complicated with peripheral neuropathy. MethodsA total of 82 T2DM patients，including 41 patients with diabetic peripheral neuropathy (DPN group)and 41patientswithout diabetic peripheral neuropathy(NDPN group)，were enrolled. Meanwhile, 80 healthy subjects were investigated as control group.BMD of lumbar and hip were measured by dual energy X-ray absorptiometry (DEXA). ResultsNDPN group had higher BMD of Ward′s area than control group(P＜0.05）,and DPN group had lower BMD of Ward′s area than NDPN group(P＜0.05).Based on the further gender stratification analysis, the above changes only existed in female patients with T2DM. No significant differences in BMD of lumbar spine, femur neck and hip were found among the three groups（P＞0.05）. ConclusionIn female patients with T2DM, BMD of Ward′s area increased before the development of peripheral neuropathy and decreased after the development of peripheral neuropathy. No significant change was found in male patients with T2DM complicated with peripheral neuropathy.［Key words］type 2 diabetes mellitus; peripheral neuropathy; bone mineral density