细胞因子对骨骼肌细胞和胰岛β细胞的作用

BACKGROUND: A variety of cytokines such as cytokines, growth factors and inflammatory proteins play an important role in the development of skeletal muscle. OBJECTIVE:To investigate the biological characteristics of a variety of cytokines and their effects on skeletal muscle cells and pancreatic β cells. METHODS: Relevant articles published from 2002 to 2015 were retrieved in CNKI and PubMed databases using the English keywords “cytokines, adiponectin, leptin, visfatin, skeletal muscle cells, pancreatic β cells”. Initially 253 literatures were obtained, and finally 53 eligible literatures were included based on the exclusion criteria. RESULTS AND CONCLUSION: As a fat-specific protein newly found, adiponectin can improve the insulin sensitivity by promoting glucose uptake, storage and utilization in skeletal muscle cells. The activation of muscle satellite cells and skeletal myoblast proliferation are both dependent on leptin, so leptin plays a vital role in the skeletal muscle cell growth and development. Visfatin, a pleiotropic cytokine, widely presents in the skeletal muscle, liver and bone marrow, and participates in the regulation of inflammation and immune function. Furthermore, visfatin contributes to glucose uptake and metabolism in the skeletal muscle, and makes considerable effects on the stress and signal transduction of skeletal muscle cells. 中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Effects of cytokines on skeletal muscle cells and pancreatic beta cells