米力农雾化治疗小儿重症肺炎合并心力衰竭的疗效

目的 探讨米力农雾化治疗新生儿及小婴儿重症肺炎合并心力衰竭的疗效及安全性。 方法 选择240例重症肺炎合并心力衰竭的患儿,随机分为对照组和观察组,每组120例。对照组给予常规洋地黄、利尿等基础治疗;观察组在对照组的基础上加用米力农雾化。观察两组临床疗效和心功能指标的变化。 结果 治疗5 d后,两组中大部分患者的临床症状、体征及心功能指标均改善,观察组治疗前后各项观察指标的改善均优于对照组,两组治疗后临床疗效和心功能指标差值比较,差异有统计学意义(P<0.05)。 结论 在常规洋地黄、利尿等治疗基础上,米力农雾化能更快地减低肺循环阻力、减少心脏前负荷和后负荷,从而有效地改善患儿心功能。

Clinical effect of milrinone atomization inhalation on treating severe pneumonia complicated with heart failure of neonates and infants

Objective To discuss the curative effect and security of milrinone atomization inhalation on treating severe pneumonia complicated with heart failure in noenates and infants. Methods A total of 240 cases with severe pneumonia complicated with heart failure in the fourth Peoples Hospital of Jinan City from 2012 to 2015 were randomly divided into control group and observation group, 120 in each group. The control group was treated with digitalis, diuretic, and other conventional therapies; on this basis, the observation group was treated additionally with milrinone atomization inhalation. Changes of the clinical efficacy and cardiac function indexes of the two groups were observed. Results After 5 days of treatment, clinical symptoms, signs and cardiac function indexes were improved significantly in the two groups. The improvement of cardiac function indexes in the observation group was better than that in the control group. The difference of clinical efficacy and cardiac function indexes before and after the treatment in the two groups were statistically significant(P<0.05). Conclusion On the basis of routine treatment such as digitalis and diuretic therapy, milrinone atomization inhalation can reduce the pulmonary circulation resistance, cardiac preload and afterload, thus effectively improve the heart function in noenates and infants with severe pneumonia complicated with heart failure.