| CAR-T抗肿瘤研究的现状及展望 |
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| 引用本文： | 郑敏,张岚. CAR-T抗肿瘤研究的现状及展望[J]. 山东大学学报(医学版), 2016, 54(11): 1-6. DOI: 10.6040/j.issn.1671-7554.0.2016.835 |
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| 作者姓名： | 郑敏 张岚 |
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| 作者单位： | 中山大学 1.肿瘤防治中心妇瘤科;2.华南肿瘤学国家重点实验室;3.肿瘤医学协同创新中心, 广东 广州 510060 |
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| 基金项目： | 国家自然科学基金(81372275);广东省省级科技计划(2016A020215080) |
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| 摘 要： | 嵌合抗原受体修饰的T细胞(CAR-T)是一种安全有效的肿瘤治疗策略。在多种血液肿瘤的临床试验中,CAR-T细胞疗法取得重大突破,在实体瘤的临床试验中也崭露头角。但在获得显著疗效的同时,CAR-T也存在脱靶效应、细胞因子风暴、插入突变、对实体肿瘤疗效有限等问题。现就CAR-T技术的最新进展及该领域有待解决的问题进行综述,为CAR-T疗法的进一步研究和临床应用提供参考。
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| 关 键 词： | 嵌合抗原受体 嵌合抗原受体修饰的T细胞 肿瘤 免疫治疗 |
| 收稿时间： | 2016-07-02 |
Current situation and development trend of CAR-T in anti-tumor research |
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| ZHENG Min,ZHANG Lan. Current situation and development trend of CAR-T in anti-tumor research[J]. Journal of Shandong University:Health Sciences, 2016, 54(11): 1-6. DOI: 10.6040/j.issn.1671-7554.0.2016.835 |
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| Authors: | ZHENG Min ZHANG Lan |
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| Affiliation: | 1. Department of Gynecology, Cancer Center;2. State Key Laboratory of Oncology in South China;3. Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University, Guangzhou 510060, Guangdong, China |
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| Abstract: | A lot of remarkable results suggested that the modification of T-cells with CARs(CRA-T)could be a powerful approach for developing safe and effective cancer therapeutics. A novel breakthrough has been made in CAR-T treatment of hematologic tumors and therapeutic potential in clinical studies of solid tumors has been achieved, although there are still many problems for CAR-T on the clinical application such as off-target effects, cytokine storm, insertion mutagenesis, limited effects for solid tumors. Here, we reviewed the recent advances of CAR-T and problems that need to be solved in this field, which provide references for the in-depth study and further clinical immunotherapy. |
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| Keywords: | Tumor Immunotherapy Chimeric antigen receptor Chimeric antigen receptor T cells |
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