2型糖尿病男性患者血清睾酮水平低下对非酒精性脂肪肝的影响

目的 探讨2型糖尿病(T2DM)男性患者血清总睾酮水平与非酒精性脂肪肝(NAFLD)的相关性。 方法 以199例T2DM男性患者为研究对象,应用腹部超声进行NAFLD的诊断及分型,根据超声诊断结果将研究对象分为NAFLD组及非NAFLD组,并根据超声检查结果将NAFLD组分为轻度NAFLD组及中-重度NAFLD组。用电化学发光法检测患者血清总睾酮(TT)水平,并检测患者相关血清学指标,分析睾酮水平与NAFLD的相关性。 结果 (1) NAFLD组的男性T2DM患者血清总睾酮水平低于非NAFLD组［3.29(2.54~4.21)vs 4.91(3.48~5.99), P<0.01］。 (2) 中-重度NAFLD患者血清总睾酮水平低于轻度患者(3.06±1.11 vs 3.65±1.45, P=0.049)。 结论 男性T2DM患者血清总睾酮水平低下者更易患NAFLD,睾酮水平低下为NAFLD的独立危险因素。

Association of serum testosterone level and non-alcoholic fatty liver disease in male patients with T2DM

Objective To investigate the correlation between serum total testosterone(TT)and non-alcoholic fatty liver disease(NAFLD)in male patients with type 2 diabetes mellitus(T2DM). Methods A total of 199 male patients with T2DM were enrolled in the study. According to results of abdomen ultrasound, the subjects were divided into NAFLD group and non-NAFLD group. The NAFLD group was further divided into mild subgroup and moderate-severe subgroup according to the severity of NAFLD. The TT level was measured using electrochemiluminescent method. The other serological indicators were measured by Olympus automatic biochemistry analyzer. The correlation of TT and NAFLD was analyzed. Results The TT level of NAFLD group was lower than that of non-NAFLD group［3.29(2.54-4.21)vs 4.91(3.48-5.99), P<0.01］. The TT level of the moderate-severe subgroup was lower than that of the mild subgroup(3.06±1.11 vs 3.65±1.45, P=0.049). Conclusion Male T2DM patients with low TT level are at high risk of NAFLD. Low TT level is an independent risk factor for NAFLD in T2DM male patients.