Impact of patient selection in various study designs: identifying potential bias in clinical results |
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Authors: | Berbano Elizabeth P Baxi Nancy |
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Institution: | Department of Medicine, Walter Reed Army Medical Center, Washington DC 20307-5001, USA. elizabeth.berbano@amedd.army.mil |
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Abstract: | Many different study designs are used to address different types of clinical questions. The two broad categories are the experimental study, which is the randomized controlled trial, and observational studies, which includes all of the other basic study designs (cohort prospective and retrospective] studies, case-control etiologic] studies, cross-sectional prevalence] studies, case series, and case reports). These study designs address basic categories of clinical questions: treatment, diagnosis, prognosis, and harm. This article focuses on some of these study designs, highlighting the impact of patient selection, inclusion, and exclusion criteria on results and outcomes through the use of specific examples. |
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