中国心肌梗死患者血管紧张素Ⅰ转换酶基因插入/缺失多态性Meta分析

目的对中国人血管紧张素Ⅰ转换酶(ACE)基因内含子16插入(I)/缺失(D)多态性与心肌梗死的关联性进行Meta分析.方法以心肌梗死组和健康对照组基因型分布的比值比(OR)为统计量.全面检索到相关文献,剔除不符合要求的文献,排除发表偏倚的影响,应用REVMAN3.1软件对各研究结果进行一致性检验和采用相应的数学模型进行数据合并.结果相关文献未发现显著发表偏倚,数据合并结果心肌梗死组和健康对照组DD/(ID+II)OR 2.33,95%可信区间(CI)1.65～3.29,(P＜0.01),II/(ID+DD)OR 0.59,95%CI 0.47～0.73,(P＜0.01).结论中国人ACE I/D多态性与心肌梗死有关联,心肌梗死组DD基因型增多,II基因型减少.

Meta-analysis on the association of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and myocardial infarction in Chinese population

Objective: To study the association of the insertion (I)/deletion (D) polymorphism of the angiotensin-comerting enzyme gene intron 16(ACE I/D) and myocardial infarction (MI) in Chinese population by means of meta-analysis. Methods: Odds ratios (OR) of ACE I/D genotype distributions in MI patients against healthy control were analyzed. All the related studies on ACE I/D polymorphism and MI were identified; disqualified studies were excluded; the risk of publication bias was eliminated. The meta-analysis software. REVMAN3. 1, was applied for investigating heterogeneity among individual studies and summarizing effects across studies by proper statistical methods. Results: Of the 10 studies in tins meta-analysis, a total of 730 cases and 883 controls were included. No significant publication bias has been found. The pooled odds ratio (with 95% CI) of DD vs ID II is 2. 33( 1.65 - 3. 29) ( P < 0. 01 ), while the pooled odds ratio (with 95% CI)of II vs ID DD is0. 59(0.47-0. 73)( P <0. 01). Conclusion: In Chinese population. ACE I/D polymorphism is associated with MI. The number of MI patients with DD genotype increases, while that with II genotype decreases.