| 脂毒性心肌病的研究进展 |
| |
| 引用本文： | 李传保,卜培莉. 脂毒性心肌病的研究进展[J]. 心血管病学进展, 2006, 27(6): 719-721 |
| |
| 作者姓名： | 李传保 卜培莉 |
| |
| 作者单位： | 山东大学齐鲁医院心内科,教育部和卫生部心血管重构和功能研究重点实验室,山东,济南,250012 |
| |
| 摘 要： | 心脏中脂质大量积聚,可以引起心脏功能异常,称之为脂毒性心肌病。目前,脂毒性心肌病已在大量的转基因小鼠模型中发现,证明了有心脏毒性的脂质积聚与脂毒性心肌病是相关联的。研究过氧化物酶体增殖剂活化受体在脂毒性心肌病中的作用,可以为预防和治疗脂毒性心肌病提供新思路。
|
| 关 键 词： | 脂质 转基因小鼠 脂毒性心肌病 过氧化物酶体增殖剂活化受体 |
| 文章编号： | 1004-3934(2006)06-0719-03 |
| 收稿时间： | 2006-01-10 |
| 修稿时间： | 2006-06-20 |
Advances in Research of Lipotoxic Cardiomyopathy |
| |
| LI Chuan-bao,BU Pei-li. Advances in Research of Lipotoxic Cardiomyopathy[J]. Advances in Cardiovascular Diseases, 2006, 27(6): 719-721 |
| |
| Authors: | LI Chuan-bao BU Pei-li |
| |
| Affiliation: | Department of Cardiology, Qilu Hospital of Shandong University ; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan 250012, China |
| |
| Abstract: | Lipid accumulation in the heart may lead to cardiac dysfunction,which is called lipotoxic cardiomyopathy.At present,lipotoxic cardiomyopathy has been found in numerous transgenic mouse models,and proves that the accumulation of cardiotoxic lipid species is associated with lipotoxic cardiomyopathy.Studies of the role of the peroxisome proliferators-activated receptor plays in lipotoxic cardiomyopathy will provide new strategies to prevent and cure lipotoxic cardiomyopathy. |
| |
| Keywords: | lipid transgenic mice lipotoxic cardiomyopathy peroxisome proliferators-activated receptor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
