高血压病合并抑郁症患者血清甲状腺激素水平的研究

目的：探讨高血压病合并抑郁症患者血清甲状腺激素水平的变化。方法采用化学发光法分别测定高血压病合并抑郁症组（n＝50）、高血压病组（n＝50）、抑郁症组（n＝50）、健康对照组（n＝50）的血清甲状腺激素FT3、FT4、TSH水平并进行比较。结果高血压病合并抑郁症组的FT3浓度明显低于高血压病组、抑郁症组和健康对照组（ P＝0.036， P＝0.041， P＝0.000）。四组中低T3综合征的发生率分别为：35.0％、22.0％、12.0％、4.0％，且差异有显著性（χ2＝10.821， P＝0.010）。高血压病合并抑郁症组的血清FT3浓度与高血压病分级、汉密顿（HAMD）量表总分均呈负相关（P＝0.000，P＝0.013）。控制HAMD量表总分时，其FT3浓度与高血压病分级的偏相关系数为-0.584，P＝0.000。控制高血压病分级时，其FT3浓度与HAMD量表总分的偏相关系数为-0.365，P＝0.044。结论高血压病合并抑郁症患者的血清FT3浓度明显下降，更易发生低T3综合征，且其FT3浓度与高血压病分级、HAMD量表总分之间均存在负相关关系，FT3水平可以作为判断高血压病合并抑郁症患者病情严重程度的指标之一，对判断预后及指导治疗具有重要意义。

Study of serum thyroid hormone in hypertension patients with depression

Objective To study the alteration of serum thyroid hormone FT 3, FT4, TSH in hypertension patients with depression .Methods The serum FT3, FT4, TSH levels were measured with chemiluminescence in hypertension patients with depression group （n=50）,hypertension group（n=50）,patients with depression（n=50）, healthy control group （ n=50 ） and then compared .Results The serum FT3 concentrations of hypertension patients with depression group were significantly lower than the other three groups （ P=0.036 , P=0.041 , P=0.000 ） .Its serum FT4 concentrations were significantly lower than the healthy control group （ P=0.028 ） .The incidence rate of low T3 syndrome in four groups respectively were 35.0%,22.0%,12.0%,4.0% and difference between them was significant （χ2 =10.821 , P=0.010 ） .There was a negative correlation between the serum FT 3 concentrations of hypertension with depression group and hypertension grade , Hamilton depression scale （ HAMD ） total score （ P =0.000,P=0.013）.Control the HAMD total score,the partial correlation coefficient of the FT3 concentrations and hypertension grade was -0.584,P=0.000.Control the hypertension grade ,the partial correlation coefficient of the FT3 concentrations and the HAMD total score was -0.365 ,P=0.044 .Conclusion The serum FT3 concentrations of hypertension patients with depression were significantly decreased and had a higher prevalence of low T 3 syndrome.There was a negative correlation between the serum FT 3 concentrations and hypertension grade ,HAMD score.The level of FT3,as one of the indicators of evaluating the severity of hypertension patients with depression ,had a great significance to determine the prognosis and guide the treatment .