泌尿生殖道支原体培养及耐药性变迁研究

目的探讨北京地区2002~2005年间泌尿生殖道支原体感染状况及其耐药性变化,为临床合理用药提供参考。方法采用法国生物-梅里埃公司IST2试剂盒检测支原体及药敏。结果1806例标本中检出673例支原体,检出率为37.3%,其中解脲脲支原体(Uu)541例占80.4%,解脲脲支原体合并人支原体(Uu Mh)107例占15.9%,人支原体(Mh)25例占3.7%;总药敏趋势表明普那霉素(敏感率98.7%)、交沙霉素(敏感率92.6%)敏感性较高且较稳定,多西环素(敏感率91.8%),其次,四环素和红霉素敏感呈增强趋势,环丙沙星和氧氟沙星敏感率最低;不同性别、不同型别支原体对抗菌药物敏感性亦不同。结论加强支原体药敏检测,根据药敏结果合理用药,无条件进行药敏检测时,治疗支原体感染宜首选交沙霉素。

Urogenital Mycoplasma Infection and Antibiotic Susceptibility

OBJECTIVE To investigate urogenital mycoplasma infection and its drug sensitivity in Beijing from Jul 2002 to Jun 2005. METHODS Mycoplasma were isolated and their antibiotic susceptibility was detected with Mycoplasma IST 2 Reagent Box from France. RESULTS Among 1806 cases 673 cases were with positive mycoplasma,accounting for 37.3% of the total.From them,Ureaplasma urealyticum(Uu) was positive in 541 cases(80.4%),higher than Uu combined with Mycoplasma hominis(Mh) infection(107 cases,15.9%) or Mh alone infection(25 cases,3.7%).The result of drug sensitivity test showed that Uu,Mh and Uu Mh isolated from both sexes had different drug resistance.The most sensitive and stable antibiotics were josamycin(the rate of sensitivity was 98.7%) and pristinamycin(the rate of sensitivity 92.6%),the next was doxycyline(the rate of sensitivity was 91.8%).It seemed increasing sensitivity trend for tetracycline and erythromycin.The lowest rate of sensitivity was to ofloxacin and ciprofloxacin. CONCLUSIONS It is important to enhance the detection of drug resistance of mycoplasma,guide the drug use and prevent from producing antibiotic resistance.If antibiotic susceptibility testing of mycoplasma can not be tested,josamycin may be selected as the first choice to treat mycoplasma infection.