| 尖锐湿疣患者皮损及外观正常皮肤表皮中P21~(ras)和c-myc的表达 |
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| 引用本文： | 庞晓文,赵广,孟如松,张红.尖锐湿疣患者皮损及外观正常皮肤表皮中P21~(ras)和c-myc的表达[J].中国皮肤性病学杂志,2006,20(5):264-266,275. |
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| 作者姓名： | 庞晓文 赵广 孟如松 张红 |
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| 作者单位： | 中国人民解放军空军总医院皮肤科,北京,100036 |
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| 摘 要： | 目的探讨P21ras和c-myc在尖锐湿疣(CA)发病机理中的作用。方法采用免疫组化二步法检测15例CA损害中P21ras和c-myc的表达情况,并与CA非皮损、正常人表皮及高分化鳞癌皮损组织作对照。结果CA皮损中P21ras阳性细胞广泛分布于基底层、棘层、颗粒层中,在表皮各层中其表达均显著强于正常人组(P<0.05),与CA非皮损组及鳞癌组比较差异无显著性(P>0.05);在CA皮损中c-myc蛋白在表皮各层中的表达均强于正常人组(P<0.05),与CA非皮损组比较差异无显著性(P>0.05),在棘层、颗粒层中的表达则弱于鳞癌组(P<0.05)。结论c-ras是参与细胞信号传导的重要的原癌基因,在CA表皮增殖信号传导过程中发挥重要作用。转录因子c-myc蛋白可直接与DNA作用,促进与增殖有关的基因开放,导致角质形成细胞的过度增殖。
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| 关 键 词： | 尖锐湿疣 P21ras c-myc |
| 文章编号： | 1001-7089（2006）05-0264-03 |
| 收稿时间： | 2005-06-15 |
| 修稿时间： | 2005-06-152006-03-01 |
Expression of P21ras and c-myc in Lesion and Non-lesion Epidermis of Condyloma Acuminatum |
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| PANG Xiao-wen,ZHAO Guang,MENG Ru-song,et al.Expression of P21ras and c-myc in Lesion and Non-lesion Epidermis of Condyloma Acuminatum[J].The Chinese Journal of Dermatovenereology,2006,20(5):264-266,275. |
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| Authors: | PANG Xiao-wen ZHAO Guang MENG Ru-song |
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| Affiliation: | Department of Dermatology ,Air Force General Hospital PLA ,Beijing 100036, China |
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| Abstract: | Objective To investigate the function of P21~(ras) and c-myc in pathogenesis of Condyloma Acuminatum(CA).Methods The expression of P21~(ras) and c-myc in lesion specimens from 15 patients with CA were examined with immunohistochemistry,compared in non-lesion specimens with CA,normal skin and lesion specimens with Squamous Cell Carcinoma(SCC).Results The expression level of P21~(ras) and c-myc in lesion specimens with CA was higher than that in normal skin(P<0.05).In lesion specimens with CA,the expression level of c-myc in spinal layer and granulous layer was lower than that in lesion specimens with SCC(P<0.05).Conclusion Our results suggested that increased expression of P21~(ras) and c-myc in CA is associated with the hyperplasia of CA. |
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| Keywords: | P21ras c-myc |
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