疟原虫入侵红细胞的相关分子及其机制

疟原虫入侵宿主红细胞具有高度的种特异性,这些特异性的分子基础是疟原虫蛋白质与宿主红细胞表面蛋白质的相互作用.寻找参与疟原虫入侵红细胞的相关分子及其入侵机制是疟疾研究领域的热点.针对疟原虫不同种和虫株的实验研究并结合生物信息学分析结果表明:裂殖子表面蛋白、网织红细胞结合蛋白家族、红细胞结合蛋白家族以及动力蛋白等是参与疟原虫入侵红细胞的重要蛋白.该文对这方面的研究进展作了系统的综述,并阐述这些蛋白质在疟原虫入侵过程不同阶段中的作用.

Molecules and mechanism involved in invasion of malaria parasites to erythrocyte

Different Plasmodium species utilize specific set of ligand-receptor interactions accounting for the distinct invasive behavior of merozoites. Most studies on host cell invasion by Plosmodium are concentrated on red blood cell invasion. The members of proteins involved in erythrocyte-invasion processes, such as MSPs, EBL family, RBL family and motor protein have been identified with the help of classical studies and bioinformatic analysis. This review summarized the role of these proteins in the merozoite invasion processes.