左氧氟沙星四联疗法根除幽门螺杆菌疗效观察

目的探讨左氧氟沙星四联疗法根除幽门螺杆菌（Helicobacter pylori,Hp）的疗效。方法连续收集168例Hp阳性慢性胃炎和消化性溃疡患者,随机分为观察组和对照组。观察组给予泮托拉唑、阿莫西林、左氧氟沙星、枸橼酸铋钾口服。对照组给予泮托拉唑、阿莫西林、甲硝唑、枸橼酸铋钾口服。以上药物均为2次/d,疗程7 d。从第8天开始两组患者均继续给予泮托拉唑,1次/d,口服3周。治疗结束至少4周后Hp的状态用13C-呼气试验进行检测。结果观察组及对照组的Hp根除率分别为92.86%（按意向性处理分析,ITT分析）与78.57%（ITT分析）,两组比较,差异有统计学意义（P〈0.05）;两组的溃疡愈合率分别为94.12%（ITT分析）与93.75%（ITT分析）,差异无统计学意义（P〉0.05）。两组的不良反应发生率分别为8.33%（ITT分析）与9.52%（ITT分析）,差异无统计学意义（P〉0.05）。结论左氧氟沙星四联疗法根除Hp疗效好,安全性高。

Curative Effects of Levofloxacin Quadruple Therapy on Adults with Helicobacter Pylori Infection

Objective To explore the clinical efficacy of levofloxacin quadruple therapy in eradicating Helicobacter pylor（H.pylori）.Methods 168 patients with H.pylori-positive chronic gastritis and peptic ulcer were randomly divided into study group and control group.The study group was treated with pantoprazole,amoxicillin,levofloxacin and bismuth potassium citrate orally.The control group received pantoprazole,amoxicillin,metronidazole and bismuth potassium citrate orally.These drugs are all given twice a day for 7 days.From the 8th days,patients in both groups continued to be treated with pantoprazole once a day orally for 3 weeks.More than 4 weeks after completion of treatment,H.pylori status was assessed by 13C-urea breath test.Results The H.pylori eradication rate of the study group was 92.86%（analysis by intent of treatment,ITT analysis）,and was 78.57% of the control group（ITT analysis）,the difference was statistically significant（P〈0.05）.The ulcer healing rate of the study group was 94.12%（ITT analysis）,and was 93.75% in the control group（ITT analysis）,the difference between the two groups was not statistically significant（P〉0.05）.The adverse events rates of the study group and control group were 8.33%（7/84） and 9.52%（8/84）（ITT analysis） respectively,the difference was not statistically significant（P〉0.05）.Conclusion It is more effective and safe to apply levofloxacin quadruple therapy to eradicate H.pylori.