依达拉奉与奥扎格雷钠联用治疗急性脑梗死临床研究

目的探讨依达拉奉与奥扎格雷钠联用治疗急性脑梗死临床效果及安全性。方法选取我院2010年3月-2012年5月收治急性脑梗死患者160例，采用随机数字表法分为对照组和联合治疗组，每组各80例；其中对照组患者采用奥扎格雷钠静脉滴注治疗；联合治疗组；其中在对照组治疗基础上，加用依达拉奉静脉滴注治疗；比较两组患者临床改善总有效率，治疗前后神经功能缺损（NIHSS）及日常生活能力（BI）评分及不良反应发生情况等。结果对照组和联合治疗组患者临床改善总有效率分别为80．O％，93．8％；联合治疗组患者临床改善总有效率明显高于对照组，组间比较差异显著（P〈0．05）；对照组与联合治疗组患者治疗前神经功能缺损评分及BI评分组间比较无显著差异（P〉0．05）；两组患者治疗后神经功能缺损评分及BI评分较治疗前明显改善，且联合治疗组患者改善程度明显优于对照组，组问比较差异显著（P〈0．05）；同时两组患者并发症发生率组间比较无显著差异（P〉0．05）。结论依达拉奉与奥扎格雷钠联用治疗急性脑梗死临床效果确切，可显著改善神经功能缺损症状，恢复13常生活能力，且未提高并发症发生风险，具有临床使用价值。

Clinical Study of Edaravone Treatment Combined with Sodium Ozagrel on Acute Cerebral Infarction

Objective To investigate the therapeutic effect and security of edaravone treatment combined with sodium ozagrel on acute cerebral infarction. Methods 160 patients with acute cerebral infarction were chose in the period from October 2010 to March 2012 in our hospital and randomly divided into two groups including control group （80 patients） with sodium ozagrel infusion treatment and combined treatment group （80 patients） with edaravone treatment on the basis of control group treatment; and the clinical improving efficiency, the NIHSS and BI scores before and after treatment and complication occurrence of both groups were compared. Results The clinical improving efficiency of control group and combined treatment group were separately 80.0%, 93.8%; The clinical improving efficiency of combined treatment group were significantly higher than control group （P〈0.05）. There was no significant difference in NIHSS and BI scores before treatment between control group and Combined treatment group （P〉0.05）; The NIHSS and BI scores after treatment of both groups were significantly better than before treatment （P〈0.05） ; and the improving degree of combined treatment group were significantly better than control group （P〈0.05）. There was no significant difference in complication incidence between control group and Combined treatment group （P〉0.05）. Conclusion Edaravone treatment combined with sodium ozagrel on acute cerebral infarction possess perfect effects, can efficiently improve neurological deficit, restore the normal life ability, do not higher the risk of complication, and is worthy of clinical application value.