血清睾酮在中年男性冠心病患者中的表达及意义

目的:探讨中年男性冠心病患者的血清睾酮水平变化及其与冠状动脉狭窄程度的关系。方法:检测87例中年男性冠心病患者(包括稳定型心绞痛、不稳定型心绞痛及急性心肌梗塞)血清睾酮浓度。所有患者行冠脉造影,用Gensini冠脉评分评估患者冠脉狭窄程度。冠脉狭窄低于50%的患者纳入对照组。结果:稳定型心绞痛组,不稳定型心绞痛组及急性心肌梗塞组血清睾酮水平(分别为488.2±96.8ng/dL,411.6±128.6ng/dL,365.3±116.6ng/dL)显著低于对照组(562.8±110.2ng/dL)(P均<0.05)。稳定型心绞痛组,不稳定型心绞痛组及急性心肌梗塞组三组比较,急性心肌梗塞组血清睾酮水平最低,不稳定型心绞痛组居中,稳定型心绞痛组最高(P均<0.05)。血管造影Gensini得分与血清睾酮水平显著相关(n=87,r=-0.513,P<0.05)。结论:中年男性冠心病患者血清睾酮呈低水平状态,且与冠脉狭窄程度呈负相关。

Expression of serum testosterone in middle-aged male patients with coronary artery disease and its significance

Objective: To investigate the changes of testosterone level and its relationship wtih the severity of coronary artery stenosis in middle-aged men with coronary artery disease(CAD).Methods:Serum testosterone concentration was measured in 87 middle-aged male patients with CAD including stable angina pectoris(SAP),unstable angina pectoris(USAP) and acute myocardial infarction(AMI).All patients underwent coronary angiography and the severity of coronary stenosis was estimated by the Gensini coronary score.Patients with degree of coronary artery stenosis of less than 50% were served as control group.Results:The levels of testosterone in SAP group(488.2±96.8ng/dL),USAP group(411.6±128.6ng/dL) and AMI group(365.3±116.6ng/dL) were significantly lower than that in control group(562.8±110.2ng/dL)(P all <0.05).Among SAP,USAP and AMI groups,the level of testosterone in AMI group was the lowest,the USAP group was the median while the SAP group was the highest(P all <0.05).There was significant correlation between angiographic Gensini score and testosterone level(n=87,r=-0.513,P<0.05).Conclusion:The present study shows that serum testosterone level in middle-aged male patients with CAD was low and the level was negatively correlated with severity of coronary artery stenosis.