靶控输注瑞芬太尼复合丙泊酚控制性降压在脊椎手术中的应用

目的:探讨靶控输注瑞芬太尼复合丙泊酚控制性降压在脊椎手术中的应用效果。方法:选取2009年6月～2011年11月进行脊椎手术治疗的66例患者为研究对象,随机分为对照组和观察组各33例,对照组采用芬太尼复合丙泊酚进行麻醉,观察组则采用瑞芬太尼联合丙泊酚进行麻醉,将两组患者降压前、降压后10,30,60min及停止用药后10min的MAP、PgCO2、HR、CI及苏醒质量、出血量进行比较。结果:观察组降压后10,30,60min时MAP、PgCO2、HR、CI均低于对照组,而停药后10min则恢复效果也优于对照组,苏醒质量和出血量也优于对照组,P均<0.05。结论:靶控输注瑞芬太尼复合丙泊酚控制性降压在脊椎手术中的应用效果较好,且对心脏及呼吸的影响也较小。

Application of controlled hypotension by target-controlled infusion of remifentanil combined with propofol in spinal surgery

Objective: To study the application of controlled hypotension by target-controlled infusion of remifentanil combined with propofol in spinal surgery.Methods:A total of 66 patients schedulled for spinal surgery from June 2009 to November 2011 were selected,and were randomly divided into control group and observation group with 33 cases in each group.Patients in control group were given by fentanyl combined with propofol,and the observation group were given target-controlled infusion of remifentanil combined with propofol.MAP,PgCO2,HR,CI,recovery quality,and blood loss before and 10,30,60 min after antihypertensive treatment,and 10 min after drug withdrawal were observed and compared.Results:After treatment,MAP,PgCO2,HR,CI and blood loss in observation group were significantly lower than those of control group,restoration status and recovery quality after withdrawal was better than those of control group(P<0.05).Conclusions:The target-controlled infusion by remifentanil combined with propofol is effective on treating controlled hypotension patients undergoing spinal operation,and is of little influence on heart and respiratory system.