不孕不育患者支原体感染状况及药物敏感结果分析

目的:探讨不孕不育患者支原体感染状况及对12种抗生素的药敏情况,为临床合理治疗提供参考。方法:对本中心620例不孕不育患者的生殖道分泌物进行支原体培养及体外药敏试验,计算男性及女性患者支原体感染总阳性率、解脲支原体(Uu)及人型支原体(Mh)阳性率,采用卡方检验进行统计学分析。结果:支原体感染总阳性率为18.4%(114/620),男性和女性阳性率分别为13.6%(32/236)、21.4%(82/384)。男性和女性Uu阳性率分别为3.4%(8/236)、16.7%(64/384);Mh阳性率分别为6.8%(16/236)、2.1%(8/384),Uu和Mh合并感染阳性率分别为3.4%(8/236)、2.6%(10/384)。女性患者与男性患者支原体感染阳性率、Uu感染率、Mh感染率以及女性患者的Uu与Mh感染率间差异有统计学意义(P均<0.05)。Uu感染对美满霉素的敏感性最高(100.0%),对环丙沙星的耐药性最强(41.6%);Mh感染对美满霉素的敏感性最高(100.0%),对红霉素、环酯红霉素和克拉霉素的耐药性均达到50.0%;Uu和Mh混合感染对美满霉素的敏感性最高(77.8%),对12种抗生素均有不同程度的耐药性,其中对红霉素的耐药性最强(77.8%)。结论:男性和女性患者支原体感染状况不同,治疗时建议根据药敏结果合理用药。

Analysis of mycoplasma infection and drug sensitivity test results in infertile patients

Objective:To explore the status of mycoplasma infection in infertile patients and its sensitivity to twelve antibiotics to provide a basis for the clinical rational use of drugs.Methods:Genital-tract secretions of 620 infertile patients were taken for mycoplasma culture and antibiotics sensitivity test.The positive rates of mycoplasma,ureaplasma urealyticum(Uu) and mycoplasma hominis(Mh) were calculated,and Chi-square test was used for statistical analysis.Results:The positive rate of mycoplasma infection in infertile patients was 18.4%(114/620),and those of the female and male groups were 21.4%(82/384) and 13.6%(32/236),respectively.The positive rate of Uu infection in the female group was 16.7%(64/384) and that in the male group was 3.4%(8/236).The positive rate of Mh infection in the female group was 2.1%(8/384) and that in the male group was 6.8%(16/236).The positive rate of Uu and Mh co-infection in the female group was 2.6%(10/384) and that in the male group was 3.4%(8/236).There were significant differences in positive rates of mycoplasma,Uu and Mh infections between the female and male groups(P all <0.05).And there was significant difference between the Uu and Mh infection in the female group(P<0.05).Drug sensitivity test results showed that Uu infection sensitive to Mincycline was up to 100.0%(72/72) and resistant to ciprofloxacin was up to 41.6%(30/72);Mh infection sensitive to Mincycline was up to 100.0%(24/24) and resistant to erythromycin,erythromycin ring ester and clarithromycin reached 50%.The Uu and Mh co-infection sensitive to Mincycline was up to 77.8%(14/18) and had different levels of resistance to twelve kinds of antibiotics,and the resistance to erythromycin was up to 77.8%.Conclusion:Mycoplasma infection is high in infertile patients,but shows different characteristics in male and female patients.Mycoplasma infection should be treated according to the drug sensitivity test results.