米非司酮对子宫内膜异位症治疗前后IL-6和TNF水平的影响

目的:探讨米非司酮治疗子宫内膜异位症(EMs)术后白细胞介素-6(IL-6)、肿瘤坏死因子-a(TNF-a)水平的变化情况。方法:EMs术后患者108例随机分为米非司酮治疗组和对照组(未用药),每组54例,另选择健康体检者52例作为正常组,采用ELISA检测正常组及两组患者术前、术后3d、术后12周IL-6及TNF-a水平,并进行比较。结果:术前不同分期(I～Ⅱ期、Ⅲ～Ⅳ期)EMs患者及米非司酮治疗组、对照组IL-6及TNF-a水平均明显高于正常组(P均<0.01),术后与正常组无明显差异(P均>0.05);两组术后3d、12周IL-6、TNF-a水平与术前相比差异有统计学意义(P均<0.01),米非司酮治疗组术后12周IL-6、TNF-a水平低于对照组,但差异无统计学意义(P均>0.05);术前、后IL-6与TNF-a有明显相关性(P<0.05)。结论:EMs术后应给予药物治疗,IL-6及TNF-a水平可用于监测EMs治疗效果,也可作为判断EMs早期复发的指标。

Influence of mifepristone on IL-6 and TNF level in patients with endometriosis before and after undergoing surgery treatment

Objective: To investigate the influence of mifepristone on IL-6 and TNF level in patients with endometriosis after undergoing surgery.Methods:A total of 108 patients with endometriosis that underwent treatment were randomly divided into treatment group and control group with 54 cases in each group.Fifty-two healthy volunteers were also enrolled as normal control group.IL-6 and TNF level before undergoing surgery,3 days and 12 weeks after undergoing treatment were detected with ELISA and compared among the three groups.Results:Before undergoing surgery,IL-6 and TNF levels in the study group(was given mifepristone) and control group were significant higher than that in the normal control group(P all <0.05).But after undergoing surgery,no significant difference in IL-6 and TNF levels were observed.Three days and 12 weeks after undergoing surgery,IL-6 and TNF levels were significantly different from that before the surgery(P<0.01).After mifepristone treatment for 12 weeks,the IL-6 and TNF levels in treatment group was significant lower than that in the control group,correlation between IL-6 and TNF levels were observed.Conclusions:Drug treatment is necessary for patients undergoing Ems,IL-6 and TNF-EM levels can be used for monitoring treatment efficacy of Ems,and prediction of early recurrence.