Making personalized medicine a reality: the challenges of a modern translational research biopsy-driven program in an academic setting: the Segal Cancer Center experience |
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Authors: | Adriana Aguilar-Mahecha Zuanel Diaz Marguerite Buchanan Cristiano Ferrario André Lisbona Errol Camlioglu Carole Séguin Mark Basik |
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Institution: | 1. Department of Oncology, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, QC, H3T1E2, Canada 2. Department of Radiology, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, QC, H3T1E2, Canada
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Abstract: | The success of personalized medicine in the oncology clinic is very dependent on the results from a translational research effort to identify individual and host molecular biomarkers to enable proper selection of anti-cancer therapy. For this to happen, it is necessary to obtain timely access to high-quality biological samples of both host and tumor tissues and biological fluids. At the Segal Cancer Center, we have initiated several prospective sample collections based on research-driven breast biopsies in different contexts, including primary and metastatic breast lesions in patients receiving specific treatments. We here describe some of the challenges involved in such a translational research program and our experience in setting up biopsy-driven research protocols, highlighting the human aspects of conducting these complex enterprises. |
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