| 磁性阿霉素隐形脂质体对裸鼠移植性人胃癌疗效研究 |
| |
| 引用本文： | 柳益书,姚礼庆,周平红,沈锡中,陆伟跃,姚明,吴直江,孙亚军. 磁性阿霉素隐形脂质体对裸鼠移植性人胃癌疗效研究[J]. 江苏大学学报(医学版), 2004, 14(2): 93-96 |
| |
| 作者姓名： | 柳益书 姚礼庆 周平红 沈锡中 陆伟跃 姚明 吴直江 孙亚军 |
| |
| 作者单位： | 江苏大学附属医院普外科,江苏,镇江,212001;复旦大学附属中山医院普外科,上海,200032;复旦大学药学院,上海,200032;上海市肿瘤研究所,上海,200000;中国科学院上海细胞生物学研究所;江苏大学附属医院病理科,江苏,镇江,212001 |
| |
| 基金项目： | 国家 8 63高技术发展计划基金资助项目 ( 2 0 0 1-AA -2 180 11) |
| |
| 摘 要： | 目的：研究磁性阿霉素隐形脂质体对裸鼠移植性人胃癌的疗效。方法：以荷人胃癌的裸鼠作为动物模型，采用尾静脉给药方式，同时在肿瘤部位放置恒定磁场对肿瘤进行磁导向化疗。结果：磁性阿霉素隐形脂质体靶向组对人胃癌的移植瘤有显著抑制作用，体积和瘤重抑瘤率分别为71．27％和70．02％，显著高于磁性阿霉素隐形脂质体非靶向组(56．75％、50．10%)和游离阿霉素(33．48%、30．95%)组，而且对正常组织的毒副作用明显减轻。结论：磁性阿霉素隐形脂质体作为一种新型抗肿瘤药物显示了良好的应用前景。
|
| 关 键 词： | 阿霉素 磁性药物 隐形脂质体 靶向 |
| 文章编号： | 1671-7783(2004)02-0093-04 |
| 修稿时间： | 2004-03-15 |
Study on the Curative Effect of Magnetic Doxorubicin Stealth Liposome in Human Gastric Cancer Xenografts in Nude Mice |
| |
| LIU Yi-shu,YAO Li-qing,ZHOU Ping-hong,SHEN Xi-zhong,LU Wei-yue,YAO Ming,WU Zhi-jiang,SHUN Ya-jun. Study on the Curative Effect of Magnetic Doxorubicin Stealth Liposome in Human Gastric Cancer Xenografts in Nude Mice[J]. Journal of Jiangsu University Medicine Edition, 2004, 14(2): 93-96 |
| |
| Authors: | LIU Yi-shu YAO Li-qing ZHOU Ping-hong SHEN Xi-zhong LU Wei-yue YAO Ming WU Zhi-jiang SHUN Ya-jun |
| |
| Affiliation: | LIU Yi-shu1,YAO Li-qing2,ZHOU Ping-hong2,SHEN Xi-zhong2,LU Wei-yue3,YAO Ming4,WU Zhi-jiang5,SHUN Ya-jun6 |
| |
| Abstract: | Objective: To study on the curative effect of magnetic doxorubicin stealth liposome in human gastric cancer xenografts in nude mice.Methods: Human gastric cancer cell line MKN-45 were implanted into 36 nude mice.Different kinds of drug were injected through the caudal vein in 6 groups after established experimental modle.Permanent magnet were taken into tumor of targeting group.Results: The growth speed of tumor in the group of MDL( ) were significantely lower than other groups. The rate of tumor restrain in tumor weight and tumor volume of MDL( ) group were 71.27% and 70.02%,which were remarkably higher than those of the DOX and MDL(-) group(both P<0.05).The drug side-effect and toxicity of MDL( ) was significantely less than in other groups.Conclusion:Magnetic doxorubicin stealth liposome,regarding as a new kind carrier of anti-tumor drug,indicated a favorable foreground. |
| |
| Keywords: | Doxorubicin Magnetic drug Stealth liposome Targeting |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
