| 硝普钠对慢性染铅鼠脑组织中NO、SOD、MDA含量的影响 |
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| 引用本文： | 李淑华,袁宏伟,冯芹喜,梁亿红,杨勇. 硝普钠对慢性染铅鼠脑组织中NO、SOD、MDA含量的影响[J]. 中国全科医学, 2005, 8(8): 636-637 |
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| 作者姓名： | 李淑华 袁宏伟 冯芹喜 梁亿红 杨勇 |
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| 作者单位： | 1. 157000,黑龙江省牡丹江市,牡丹江医学院
2. 牡丹江市妇产医院检验科 |
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| 基金项目： | 黑龙江省教育厅资助课题(9551137) |
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| 摘 要： | 目的观察硝普钠对慢性染铅鼠脑组织中NO、SOD、MDA含量的影响。方法建立慢性染铅鼠模型,隔日灌服醋酸铅,约4周,观察给药(硝普钠)后3h、12h、24h脑组织中NO、SOD、MDA含量的变化。结果实验组NO含量升高,SOD活性增强,MDA的含量下降,各观察时点均与模型组存在显著性差异(P<0.01)。结论给予外源性硝普钠后,脑组织脂质过氧化反应减低,提示硝普钠对慢性铅中毒鼠脑组织损伤具有保护作用。
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| 关 键 词： | MDA含量 慢性染铅 硝普钠 脂质过氧化反应 SOD活性 显著性差异 脑组织损伤 慢性铅中毒 方法建立 NO含量 保护作用 鼠模型 醋酸铅 24h 实验组 外源性 |
| 修稿时间： | 2005-03-08 |
The Effect of SNP on the Content of NO,SOD,MDA in Lead-treated Mouse Brain |
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| LI Shu-hua,YUAN Hong-wei,FENG Qin-xi,et al.. The Effect of SNP on the Content of NO,SOD,MDA in Lead-treated Mouse Brain[J]. Chinese General Practice, 2005, 8(8): 636-637 |
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| Authors: | LI Shu-hua YUAN Hong-wei FENG Qin-xi et al. |
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| Affiliation: | LI Shu-hua,YUAN Hong-wei,FENG Qin-xi,et al.Mudanjiang Medical College,Mudanjiang 157000,China |
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| Abstract: | Objective To observe the effect of SNP (a sort of No donor drugs) on the content of nitric oxide (NO),Super oxide dismutase (SOD) and malondialdehyde (MDA) in lead-treated mouse brain.Methods Creating the lead exposure model of mouse by feeding PbAc for four weeks,we dynamically observed the levels of NO,SOD,MDA in lead-treated mouse brain at 3h,12h and 24h after injecting Sodium nitroprusside (SNP).Results In the experimental group,the NO content increased,SOD activity increased and MDA content decreased,and there are significant differences in the level of NO,SOD,MDA between SNP group and lead-treaded model group(P<0.01).Conclusion The SNP can protect the damage of brain in lead-treated mouse. |
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| Keywords: | Rats Lead Poisoning SNP NO SOD MDA |
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