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Blood and salivary concentrations of sulfamethoxazole and trimethoprim in man |
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| Authors: | F. B. Eatman A. C. Maggio R. Pocelinko H. G. Boxenbaum K. A. Geitner W. Glover T. Macasieb A. Holazo R. E. Weinfeld S. A. Kaplan |
| Affiliation: | (1) Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., 07110 Nutley, New Jersey;(2) Special Treatment Unit, Newark Beth Israel Medical Center, 07112 Newark, New Jersey;(3) Present address: USV Pharmaceutical Corp., 10707 Tuckahoe, New York |
| Abstract: | Saliva/blood and saliva/plasma concentration ratios were determined for sulfamethoxazole and trimethoprim following oral administration of cotrimoxazole to healthy human subjects. The mean experimentally determined saliva/plasma concentration ratios for sulfamethoxazole and trimethoprim were 0.0157 and 1.13, respectively. These values were shown to be in reasonable agreement with theoretical predictions. It was demonstrated that partitioning of drugs from saliva into the buccal must be considered in making theoretical predictions. |
| Keywords: | trimethoprim sulfamethoxazole co-trimoxazole saliva levels |
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