万拉法新对抑郁症患者血清性激素的影响

目的 探讨万拉法新对抑郁瘟患血清性激素的影响。方法 用放免法测定42例抑郁症患治疗前和治疗后1、6周末血清催乳素(PRL)、促滤泡成熟激素(FSH)、促黄体生成素(LH)、睾酮(T)、雌二醇(E2)，并与30例健康对照。结果 抑郁症组男性LH、E2和女性PRL、FSH与对照组比较明显升高。治疗后1、6周末男性患PRL、T、E2和女性PRL、T有显差异。结论 抑郁症患存在下丘脑—垂体—性腺轴内分泌异常，万拉法新可引起抑郁症患性激素分泌变异。

Sex Hormone Level Response to Venlafaxine in Depressive Patients

Objective To explore the effect of Venlafaxine on the sex hormone in depressive patients.Methods Compared with 30 cases of normal controls PRL, FSH, LH, T, E 2 concentration in 42 cases depressive patients were measured with radio-immune assay (RIA) before and after treatment.Results LH level in male and PRL, FSH level in female depressive patients were significantly higher than those of the controls, E 2 level decreased significantly in male patients. Before and 1 or 6 weeks after treatment, PRL, T, E 2 in male patients and PRL, T in female patients significantly were changed. Conclusions There may be endocrine dysfunction of hypothalamic-pituitary-sexgland axis in depressive patients. Venlafaxine may influence the serum level of sex hormone with depression.