Irritable bowel syndrome,the microbiota and the gut-brain axis |
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Authors: | Hans Raskov Jakob Burcharth Hans-Christian Pommergaard Jacob Rosenberg |
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Institution: | 1. Speciall?gecentret ved Diakonissestiftelsen, Frederiksberg, Denmarkraskov@mail.dk;3. Department of Surgery, Zealand University Hospital, University of Copenhagen, Copenhagen, Denmark;4. Centre for Perioperative Optimization, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark;5. Centre for Perioperative Optimization, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark;6. Department of Surgery, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark |
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Abstract: | Irritable bowel syndrome is a common functional gastrointestinal disorder and it is now evident that irritable bowel syndrome is a multi-factorial complex of changes in microbiota and immunology. The bidirectional neurohumoral integrated communication between the microbiota and the autonomous nervous system is called the gut-brain-axis, which integrates brain and GI functions, such as gut motility, appetite and weight. The gut-brain-axis has a central function in the perpetuation of irritable bowel syndrome and the microbiota plays a critical role. The purpose of this article is to review recent research concerning the epidemiology of irritable bowel syndrome, influence of microbiota, probiota, gut-brain-axis, and possible treatment modalities on irritable bowel syndrome. |
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Keywords: | gut-brain axis irritable bowel syndrome microbiota |
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