| 心脏停跳复苏犬大脑组织内皮素-1含量和Na+-K+ ATP酶活性的变化 |
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| 引用本文： | 金修才,杨兴易,赵良,许永华,景炳文,王永进. 心脏停跳复苏犬大脑组织内皮素-1含量和Na+-K+ ATP酶活性的变化[J]. 中国急救医学, 2000, 20(8) |
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| 作者姓名： | 金修才 杨兴易 赵良 许永华 景炳文 王永进 |
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| 作者单位： | 上海第二军医大学附属长征医院急救科,200003 |
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| 摘 要： | 目的 研究犬心脏停跳及复苏后脑组织内皮素 - 1(Endothelin ,ET - 1)含量、Na -K ATP酶活性的变化 ,探讨ET - 1在复苏后脑损伤中的可能作用机制。方法 采用犬室颤心跳呼吸骤停模型 ,进行标准心肺复苏 ,分别观察室颤前、心脏停跳 10min及复苏后 30min、2h和 4h的脑组织ET - 1含量和Na -K ATP酶活性变化及两者之间的关系。结果 心脏停跳及复苏后脑组织ET - 1含量明显升高 ,Na -K ATP酶活性降低 ,两者呈显著负相关。结论 心脏停跳及复苏后脑组织ET - 1含量升高引起脑组织损伤 ,其可能的作用机制之一是抑制了Na -K ATP酶的活性。
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| 关 键 词： | 心脏停跳 复苏 ET-1 Na -K ATP酶 |
Changes of endothelin-1 content and Na+-K+ ATPase activity in brain tissue in resuscitated dogs after cardiac arrest |
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| JIN Xiucai,YANG Xing-yi,ZHAO Liang,et al.. Changes of endothelin-1 content and Na+-K+ ATPase activity in brain tissue in resuscitated dogs after cardiac arrest[J]. Chinese Journal of Critical Care Medicine, 2000, 20(8) |
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| Authors: | JIN Xiucai YANG Xing-yi ZHAO Liang et al. |
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| Affiliation: | JIN Xiucai,YANG Xing-yi,ZHAO Liang,et al.Emergency Department,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China [ |
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| Abstract: | Objective To investigate the possible mechanism of ET-1 in brain injury after cardiac arrest(CA)and postresuscitation.Methods The dogs with CA model of ventricular fibrillation were used to be resuscitated with standerd cardiopulmonary resuscitation.We observed the changes of ET-1 content and Na -K ATPase activity in brain tissue before ventricular fibrillation,after ten minutes of CA and postresuscitation 30 min,2 h,4 h respectively.Results ET-1 content was increased signifcantly and Na -K ATPase activity was decreased after ten minutes of CA and postresuscitation.There was a negative correlation between them.Conclusion ET-1 played a crucial role in brain tissue injury postresuscitation,one of the possible mechanism was associated with inhibition of Na -K ATPase activity. [ |
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| Keywords: | Cardiac arrest Resuscitation ET-1 Na -K ATPase |
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