抗结核药物的作用机制及结核分枝杆菌的耐药机理

结核病是一个严重的全球性疾病,随着艾滋病病毒及耐药结核菌的出现及播散成为结核病控制的又一个威胁。虽然我们有结核疫苗及抗结核药物,但控制结核病仍是一件很棘手的事情。多重耐药结核菌的不断出现给结核病的治疗带来很大的困难。为有效控制耐药结核病,我们必须了解结核菌的耐药机理。本文讨论了抗结核药物的作用机制及结核菌的耐药机理。结核菌耐药机理的阐明对耐药菌的快速分子诊断及新药的开发有重要的意义。

Mechanisms of drug action and resistance in Mycobacterium tuberculosis

Tuberculosis (TB) is a global health problem that poses increasing threat with the spread of HIV infection and drug resistant strains of Mycobacterium tuberculosis. Effective control of TB remains a significant challenge despite the availability of chemotherapy and BCG vaccine. The emergence of strains of M.tuberculosis resistant to multiple anti-tuberculosis drugs is increasing due to inadequate compliance to the lengthy TB therapy and presents a significant problem for the treatment. In order to combat the threat of drug resistant tuberculosis and to more effectively control the disease, an understanding of the mechanisms underlying drug resistance is necessary. Mechanisms of action and resistance of major anti-tuberculosis drugs are reviewed in this article. This knowledge could be used for the development of molecular tests for rapid ~detection of drug resistant strains and for the design of new anti-tuberculosis drugs.