| 盐酸洛美沙星葡萄糖注射液细菌内毒素检查法的应用 |
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| 引用本文： | 韩翠艳,翟伟宇,程国平.盐酸洛美沙星葡萄糖注射液细菌内毒素检查法的应用[J].中国药房,2002,13(5):299-300. |
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| 作者姓名： | 韩翠艳 翟伟宇 程国平 |
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| 作者单位： | 齐齐哈尔医学院附属第一医院药剂科,齐齐哈尔市161041 |
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| 摘 要： | 目的 :研究盐酸洛美沙星葡萄糖注射液的细菌内毒素检查方法。方法 :参照《中国药典》2000年版 (二部 )收载的细菌内毒素检查法及其指导原则进行干扰试验。结果 :盐酸洛美沙星葡萄糖注射液对鲎试剂的凝集反应有干扰作用 ,调节药液 pH值至6 8～7 2可消除干扰 ,用灵敏度为0 25EU/ml的鲎试剂可进行细菌内毒素检查。结论 :可以用细菌内毒素检查法控制盐酸洛美沙星葡萄糖注射液的质量
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| 关 键 词： | 洛美沙星注射液 鲎试剂 细菌内毒素 干扰试验 |
| 文章编号： | 1001-0408(2002)05-0299-02 |
| 修稿时间： | 2001年9月20日 |
Study on the Bacterial Endotoxin Test for Lomefloxacin Hydrochloride and Glucose Injection |
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| HAN Cuiyan,ZHAI Weiyu,CHENG Guoping.Study on the Bacterial Endotoxin Test for Lomefloxacin Hydrochloride and Glucose Injection[J].China Pharmacy,2002,13(5):299-300. |
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| Authors: | HAN Cuiyan ZHAI Weiyu CHENG Guoping |
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| Abstract: | OBJECTIVE:To study the bacterial endotoxin test for lomefloxacin hydrochloride and glucose injection.METHODS:According to the assigned method and guiding principle for bacterial endotoxin test in CHINESE PHARMACOPOEIA 2000,the interference test was performed.RESULTS:Lomefloxacin and glucose injection could interfere with limulus test,however,the interference could be eliminated after adjusting the pH of injection to 6.8～7.0.The proper concentration of limulus test agent of bacterial endotoxin test was 0.25EU/ml.CONCLUSION:Bacterial endotoxin test can be used for quality control of lomefloxacin and glucose injection. |
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| Keywords: | lomefloxacin injection limulus test agent bacterial endotoxin interference test |
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