| DAC－树脂血液灌流对阿霉素肝血管内输注所致心脏毒性的预防保护作用 |
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| 引用本文： | 刘宁虎,钮振. DAC－树脂血液灌流对阿霉素肝血管内输注所致心脏毒性的预防保护作用[J]. 重庆医科大学学报, 1994, 0(1) |
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| 作者姓名： | 刘宁虎 钮振 |
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| 作者单位： | Liu Yuhu，et al Artificial Liver Rescarch Laboratory |
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| 摘 要： | 研究大鼠肝血管局部输注ＡＤＭ，与ＤＡＣ－树脂ＤＨＰ联合应用，观察对心肌组织ＭＤＡ含量及心肌超微结构的影响。结果表明，与对照组比较，能明显降低心肌ＭＤＡ含量，在联合应用后２小时和８天分别为０．４０５４±０．０４９７对０．７１２９±０．１６３１ｎｍｏｌ／ｍｇＣｐｒｏ（Ｐ＜０．００５）和０．５５０４±０．０６２８对０．７４５２±０．０６１２ｎｍｏｌ／ｍｇＣｐｒｏ（Ｐ＜０．００５）。超微结构结果显示联合应用均能明显减轻ＡＤＭ所致急性和亚急性心肌损害的程度。研究结果表明，联合应用能减轻ＡＤＭ所致自由基导致心肌脂质过氧化的程度，明显减轻心肌形态学的损害程度。
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| 关 键 词： | 吸附剂；血液灌流；阿霉素；毒性作用 |
PROTECTION OF THE CARDIAC TOXIOITY INDUCED BY INTRA-PORTAL ADRIAMYCIN INFUSION BY THE DAC-RESIN HEMOPERFUSION |
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| Liu Yuhu,et al Artificial Liver Rescarch Laboratory. PROTECTION OF THE CARDIAC TOXIOITY INDUCED BY INTRA-PORTAL ADRIAMYCIN INFUSION BY THE DAC-RESIN HEMOPERFUSION[J]. Journal of Chongqing Medical University, 1994, 0(1) |
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| Authors: | Liu Yuhu et al Artificial Liver Rescarch Laboratory |
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| Abstract: | The aim of our study was to invcstigato the protectivc influence of the DA C-Resinhemopcrfusion in combined use with the intra-portal adriamycin(ADM) infusion on the cardiactoxicity induced by the ADM. The results showed a favorable effect as revealed in diminishing theMDA content in cardiac muscle. Tho cardiac damages demonstrated by tho ultratructural changesin acute and subacute stage after the intra-portal adriamycin infusion had also been definitelyalleviated by combined use as compared with the control groups after 2 h and 8 days of AD Minfusion.It indicated that the combined administration of DAC-Resin hemoperfusion with intra-portaladriamycin infusion might diminish the action of lipoperoxidation in the cardiac muscle and cardiacmuscle damage as well. |
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| Keywords: | Adsorbent Hemoperfusion Adriamycin Intoxication |
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