| 组胺H2受体阻滞剂阻断再生障碍性贫血患者CD8＋细胞抑制正常… |
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| 引用本文： | 汪明春,杨力建.组胺H2受体阻滞剂阻断再生障碍性贫血患者CD8＋细胞抑制正常…[J].中华血液学杂志,1997,18(4):177-179. |
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| 作者姓名： | 汪明春 杨力建 |
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| 摘 要： | 目的：探讨再生障碍性贫血（再障）患者ＣＤ８＋细胞的组胺Ｈ２受体在造血抑制中的作用。方法：在１７例正常人粒－巨噬细胞集落（ＣＦＵ－ＧＭ）培养体系中分别加入１７例再障患者外周血ＣＤ８＋细胞，再患者外周血ＣＤ８＋细胞＋甲氰咪胍和单加甲氰咪胍。结果：再障患者外周血ＣＤ８＋体外能抑制正常人骨髓细胞ＣＦＵ－ＧＭ的生长，０．５×１０＾－５ｍｏｌ／Ｌ和１．０×１０＾－５ｍｏｌ／Ｌ的甲氰咪胍有解除帝种抑制作用。１．
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| 关 键 词： | 组胺H2 再生障碍性贫血 粒巨噬细胞集落 |
The in vitro inhibitory effect of CD8+ cells from patients with aplastic anemia on normal CFU-GM growth was blocked by cimetidine] |
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| M Wang,L Yang,X Guo,S Chen,J Liao.The in vitro inhibitory effect of CD8+ cells from patients with aplastic anemia on normal CFU-GM growth was blocked by cimetidine][J].Chinese Journal of Hematology,1997,18(4):177-179. |
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| Authors: | M Wang L Yang X Guo S Chen J Liao |
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| Institution: | Department of Hematology, Medical College of Jinan University, Guangzhou 510632. |
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| Abstract: | OBJECTIVE: To investigate the effect of histamine type II (H2) receptors on the inhibition of hematopoiesis by CD8+ cells from aplastic anemia (AA) patients. METHODS: The effects of CD8+ cells and/or cimetidine, alone or in combination, on normal human CFU-GM growth were studied by using CFU-GM assay. RESULTS: The CD8+ cells from the peripheral blood of AA patients significantly suppressed the growth of normal allogeneic CFU-GM. This inhibitory effect could be blocked by 0.5 x 10(-5) mol/L or 1.0 x 10(-5) mol/L cimetidine. 1.0 x 10(-5) mol/L cimetidine alone slightly inhibited the growth of normal CFU-GM, but 0.5 x 10(-5) mol/L cimetidine did not. CONCLUSION: H2 receptor antagonist cimetidine abolished the suppressive effect of AA patients CDB+ cells on the growth of normal CFU-GM. |
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