| 伴染色体t（8;21）为特征的四倍体克隆的急性白血病二例 |
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| 引用本文： | 薛永权,潘涌.伴染色体t（8;21）为特征的四倍体克隆的急性白血病二例[J].中华血液学杂志,1997,18(5):240-242. |
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| 作者姓名： | 薛永权 潘涌 |
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| 作者单位： | 江苏省血液学研究所，苏州医学院附属第一医院 |
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| 摘 要： | 目的：报道２例以染色体ｔ（８；２１）为特征的四倍体克隆白血病。方法：用Ｒ显带法对２例急性髓细胞白血病Ｍ２型（ＡＭＬ－Ｍ２）患者骨髓细胞染色体核型进行分析。结果：２例患者除正常细胞外，各有３个相关异常克隆：４６，ＸＹ，ｔ（８；２１）（２％）、４６，ＸＹ，ａｄｄ（７）（ｑ３１），ｔ（８；２１）（６．８％）和９２，ＸＸＹＹ，ａｄｄ（７）（ｑ３１）×２，ｔ（８；２１）×２（８０．６％），见于例１；４６，ＸＸ，ｔ（８；２１）（１３．４％）、４７，ＸＸ，＋４，ｔ（８；２１）（４６．３％）和９４，ＸＸＸＸ，＋４×２，ｔ（８；２１）×２（３９．１％），见于例２。２例化疗后均未获完全缓解且分别生存４和６个月。结论：四倍体或近四倍体克隆与Ｍ２／ｔ（８；２１）白血病有特别的联系且为其继发性改变，通常意味着预后不良。
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| 关 键 词： | 染色体易位 四倍体 白血病.髓细胞性.急性 |
Tetraploid clones characterized by double 8;21 translocations in two patients with acute myeloid leukemia |
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| Xue Yongquan,Pan Yong,Liu Zhenghui,et al..Tetraploid clones characterized by double 8;21 translocations in two patients with acute myeloid leukemia[J].Chinese Journal of Hematology,1997,18(5):240-242. |
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| Authors: | Xue Yongquan Pan Yong Liu Zhenghui |
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| Institution: | Jiangsu Institute of Hematology, First Affiliated Hospital of Suzhou Medical College, Suzhou 215006. |
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| Abstract: | OBJECTIVE: To report two cases of leukemia with t(8;21) and tetraploid clones. METHODS: R-banding technique was used. RESULTS: Cytogenetic studies of BM cells at diagnosis revealed that each of the two cases had three related abnormal clones besides a normal one: 46, XY, t(8;21) (2%), 46, idem, add((7)(q31)(6.8%) and 92, idem x 2 (80.6%) in case 1 and 46, XX, t(8;21) (13.4%), 47, idem, + 4 (46.3%) and 94, idem x 2 (39.1%) in case 2. They did not obtain complete remission on chemotherapy and survived 4 and 6 months, respectively. CONCLUSION: Tetraploid or near tetraploid clones are secondary events which are specifically associated with t(8;21) leukemia and the prognosis of patients with this kind of abnormal karyotype is poor. |
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| Keywords: | Chromosome translocation Tetraploidy Leukemia myeloid acute |
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