| 氧化砷对白血病细胞内PML／PML—RARa蛋白的影响 |
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| 引用本文： | 倪建华,陈国强.氧化砷对白血病细胞内PML／PML—RARa蛋白的影响[J].中华血液学杂志,1997,18(1):32-34. |
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| 作者姓名： | 倪建华 陈国强 |
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| 摘 要： | 探讨急性早幼粒细胞白血病的分子标志ＰＭＬ－ＲＡＲａ在氧化砷诱导的细胞凋亡中的可能作用。观察Ａｓ２Ｏ３对ＰＭＬ－ＲＡＲａ蛋白在亚细胞定位的影响。结论Ａｓ２Ｏ３诱导细胞凋亡的过程不依赖维甲酸信号途径，可能通过ＰＭＬ／ＰＭＬ－ＲＡＲａ及其它相关基因或蛋白的主财控来实现。
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| 关 键 词： | 氧化砷 蛋白 急性白血病 |
Effects of arsenic trioxide on the subcellular localization of PML/PML-RARalpha protein in leukemic cells] |
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| J Ni,G Chen,J Zhu,H Zhong,W Tang,X Li,S Xiong,Z Shen,S Chen,Z Wang,L Chen.Effects of arsenic trioxide on the subcellular localization of PML/PML-RARalpha protein in leukemic cells][J].Chinese Journal of Hematology,1997,18(1):32-34. |
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| Authors: | J Ni G Chen J Zhu H Zhong W Tang X Li S Xiong Z Shen S Chen Z Wang L Chen |
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| Institution: | Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Second Medical University 200025. |
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| Abstract: | OBJECTIVE: In order to illustrate the possible roles of PML-RARalpha protein in arsenic trioxide (AsO3)-induced NB4 cell apoptosis. METHODS: Effects of As2O3 on the subcellular localization of PML-RARalpha in NB4 cells were studied. RESULTS: (1) Anti-PML serum staining was reduced and PML granules emerged in the perinuclear cytoplasm in a diffuse pattern in HL-60 cells under As2O3 treatment; (2) abnormal PML/PML-RARalpha granules were decreased; (3) NB4 cells accumulated anti-PML serum staining granules in the cytoplasms were increased and similar accumulation also found in apoptotic cells; and (4) pretreatment with all-trans retinoic acid (ATRA) for 24 or 48 hours did not alter the As2O3 effects. CONCLUSION: As2O3-induced apoptosis was independent of the retinoic acid signal pathway, and it might be regulated by PML/PML-RARalpha and/or other related genes. |
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