| 环孢霉素A逆转复发难治性白血病多药耐药的临床研究 |
| |
| 引用本文： | 李晓明 吴谨绪. 环孢霉素A逆转复发难治性白血病多药耐药的临床研究[J]. 中华血液学杂志, 1997, 18(2): 73-75 |
| |
| 作者姓名： | 李晓明 吴谨绪 |
| |
| 作者单位： | 华西医科大学第一临床医学院血液科，泸州医学院附属第一医院血液科 |
| |
| 摘 要： | 目的：探讨环孢霉素Ａ（ＣｓＡ）逆转复发难治性急性白血病的临床意义及推广价值。方法：采用免疫组织化学ＡＢＣ法，ｐ１７０单抗ＪＳＢ－１检测复发难治性白血病的ｐ１７０表达，并对阳性患者随机分组，用ＣｓＡ加联合化疗进行逆转多药耐药研究，同时采用高效液相色谱法检测ＣｓＡ血药浓度，探讨ＣｓＡ血药浓度和逆转疗效间的关系。结果：ｐ１７０在复发难治性白血病中有高表达；ＣｓＡ有较好逆转复发难治性白血病多药耐药的作用（Ｐ＜０．０５）；ＣｓＡ血药浓度和逆转疗效呈正相关。结论：ＣｓＡ可能成为安全有效的逆转药物，在治疗复发难治性ＡＬ中有较大临床意义及推广价值。
|
| 关 键 词： | P糖蛋白 多药耐药 逆转 白血病 |
Clinical study on reversal of multidrug resistance in refractory and relapsed acute leukemias by cyclosporin A |
| |
| Li Xiaoming,Wu Jinxu,Zhang Liansheng,et al.. Clinical study on reversal of multidrug resistance in refractory and relapsed acute leukemias by cyclosporin A[J]. Chinese Journal of Hematology, 1997, 18(2): 73-75 |
| |
| Authors: | Li Xiaoming Wu Jinxu Zhang Liansheng et al. |
| |
| Affiliation: | First Clinical Medical College, West China University of Medical Sciences, Chengdu 610041. |
| |
| Abstract: | Objective:To explore the clinical implication of reversal of multidrug resistance (MDR) by cyclosporin A (CsA) in refractory and relapsed acute leukemias.Methods:The expression of p170 was assayed by immunocytochemical method (Avidin Biotin Complex,ABC) using a monoclonal antibody JSB 1 against p170. The p170 positive cases were randomly divided into two groups:trial group (with CsA as revertant) and control group (without CsA) ,and the blood concentration of CsA was detected by HPLC.Results:The complete remission rates were 53% and 20% in trial and control group,respectively (P<0.05),and the reversing effect was positively correlated with blood concentration of CsA.Conclusion: CsA might be a safe and effective revertant, and can be applied in the treatment of refractory and relapsed acute leukemia. |
| |
| Keywords: | P glycoprotein Multidrug resistance Reversal Leukemia |
| 本文献已被 CNKI 维普 等数据库收录！ |
