| 严重型再生障碍性贫血患者血清IL—2,sIL—2R水平与免疫报制… |
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| 引用本文： | 邵宗鸿 陈克奇. 严重型再生障碍性贫血患者血清IL—2,sIL—2R水平与免疫报制…[J]. 中华血液学杂志, 1997, 18(4): 180-182 |
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| 作者姓名： | 邵宗鸿 陈克奇 |
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| 作者单位： | 中国医学科学院,中国协和医科大学血液学研究所,血液病 |
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| 摘 要： | 目的：探索严重型再生笥贫血患者自身影免疫抑制的治疗的因素。方法：采用酶联免疫法测定２２例严重型再生障碍怀贫血患者治疗前后及正常献血者血清中白细胞介素２（ＩＬ－２）的可溶性白细胞介素２肥体（ｓＩＬ－２Ｒ）结果：４０．９％和６３．６％的严重型再生生贫血患者血清中ＩＬ－２和ｓＩＬ－２Ｒ水平高于正常人，此组患者对环孢霉素Ａ或（和）抗淋巴细胞球蛋白治疗反应明显优于血清中ＩＬ－２和ｓＩＬ－２Ｒｉｇｕｇｈｉｐ３
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| 关 键 词： | 再生障碍性贫血 白细胞介素 免疫抑制剂 |
Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients] |
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| Z Shao,K Chen,G Chen,Y Zhang,T Wang,R Zou,X Zhou,Y Zhou,Y Chu. Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients][J]. Chinese Journal of Hematology, 1997, 18(4): 180-182 |
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| Authors: | Z Shao K Chen G Chen Y Zhang T Wang R Zou X Zhou Y Zhou Y Chu |
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| Affiliation: | Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020. |
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| Abstract: | OBJECTIVE: To explore factors influencing the effectiveness of immunosuppressive therapy in severe aplastic anemia (SAA). METHODS: The serum levels of interleukin-2 (IL-2) and soluble IL-2 receptor (sIL-2R) of 22 SAA patients and 15 normal controls were measured by immunoenzyme assay. RESULTS: Comparing with the normal controls, 40.9% and 63.6% of the SAA patients had higher serum levels of IL-2 (>840ng/L) and of sIL 2R (>320 x 10(3) U/L), respectively. Those who had higher IL-2 levels and higher sIL-2R levels got better responses to cyclosporin A(CsA) and CsA plus antilymphocyte globulin (ALG). CONCLUSION: The serum levels of IL-2 and sIL-2R were correlated with the responsiveness to immunosuppressive therapy in SAA patients and might be useful for directing treatment. |
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