吡格列酮对2型糖尿病患者血清视黄醇结合蛋白4和网膜素1的影响

目的 观察吡格列酮对2型糖尿病患者血清视黄醇结合蛋白4(RBP4)和网膜素1的影响.方法 选择80例新诊断2型糖尿病患者,随机分为对照组和吡格列酮组,每组40例,治疗3个月.比较两组患者治疗前后空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)及血清BBP4和网膜素1的水平变化.结果 与对照组比较,吡格列酮组治疗后FPG和HOMA-IR明显降低(P＜0.05),血清RBP4水平也明显降低(P＜0.01),而网膜素1水平明显升高(P＜0.01).Pearson相关分析显示,RBP4与FPG、体质指数及HOMA-IR呈正相关,与低密度脂蛋白呈负相关(P＜0.05)；网膜素1与低密度脂蛋白呈正相关,与FPG、体质指数及HOMA-IR呈负相关(P＜0.05).结论 吡格列酮可能通过调节血清RBP4和网膜素1水平而改善胰岛素抵抗.

The Effect of Pioglitazone on Serum RBP 4 and Omentin 1 in Type 2 Diabetes Patients

AimTo observe the effect of pioglitazone on serum retinol binding protein 4(RBP4) and omentin 1 in type 2 diabetes mellitus patients.Methods80 cases with type 2 diabetes mellitus were randomly divided into two groups:placebo group and pioglitazone group,40 cases in each group,for a period of 3 months.Levels of fasting blood glucose,insulin resistance index(HOMA-IR),serum RBP4 and omentin 1 before and after treatment were compared in the two groups.ResultsCompared with placebo group,fasting blood glucose and HOMA-IR in pioglitazone group were obviously decreased after treatment(P<0.05),the level of serum RBP4 was decreased(P<0.01),but omentin 1 was increased(P<0.01).Pearson correlation analysis showed that RBP4 was positively correlated with FPG,BMI and HOMA-IR,but negatively correlated with LDL(P<0.05).Omentin 1 was positively correlated with LDL,but negatively correlated with FPG,BMI and HOMA-IR(P<0.05).ConclusionPioglitazone can improve insulin resistance through the regulation of serum RBP4 and omentin 1 level.