The effect of tobacco exposure on maternal and fetal thyroid function |
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| Authors: | Sarah D McDonald Mark C Walker Arne Ohlsson Kellie E Murphy Joseph Beyene Sherry L Perkins |
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| Institution: | 1. Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, McMaster University, 1200 Main Street West, HSC 3N52B, Hamilton, Ontario L8N 3Z5, Canada;2. Department of Obstetrics and Gynecology, University of Ottawa, Ontario, Canada;3. Department of Paediatrics, University of Toronto, Ontario, Canada;4. Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada;5. Department of Population Health Sciences, Hospital for Sick Children, Toronto, Ontario, Canada;6. Department of Pathology and Laboratory Medicine, The Ottawa Hospital and University of Ottawa, Ontario, Canada |
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| Abstract: | ObjectiveTo determine the effect of smoking on maternal and fetal thyroid function.Study designThis prospective cohort study involved healthy women undergoing elective cesarean section for term singleton infants. Maternal and fetal thyroid indices were compared between smokers (n = 21) and non-smokers (n = 83).ResultsMaternal thyrotropin (TSH) concentrations were significantly lower in smokers than non-smokers (1.75 mIU/L versus 2.15 mIU/L, respectively, p = 0.007), with similar free thyroxine (FT4) concentrations (9.59 pmol/L versus 9.56 pmol/L, p = 0.755). For women who smoked, the correlation between the average number of cigarettes smoked per day and maternal TSH concentrations was −0.427, p = 0.054. Infants of smokers and non-smokers had similar umbilical TSH (5.43 mIU/L versus 5.82 mIU/L, p = 0.124) and FT4 concentrations (13.06 pmol/L versus 13.57 pmol/L, p = 0.049).ConclusionWe demonstrated for the first time that women who smoke during pregnancy have significantly lower TSH concentrations than non-smokers. |
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| Keywords: | Smoking Thyrotropin Thyroxine Pregnancy Cotinine |
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