| Effect of TGF-β1 on the Expression of IL-12, IL-15, IL-18, IL-4 and IL-10 in Heart Transplantation Rejection in Rats |
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| 引用本文： | 赵金平,李平,高思海,王现国,高小见. Effect of TGF-β1 on the Expression of IL-12, IL-15, IL-18, IL-4 and IL-10 in Heart Transplantation Rejection in Rats[J]. 华中科技大学学报(医学英德文版), 2007, 27(6): 643-645. DOI: 10.1007/s11596-007-0605-0 |
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| 作者姓名： | 赵金平 李平 高思海 王现国 高小见 |
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| 作者单位： | Department of Thoracic and Cardiac Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Cardiac Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Thoracic and Cardiac Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Thoracic and Cardiac Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Thoracic and Cardiac Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Wuhan 430030 China，Wuhan 430022 China，Wuhan 430030 China，Wuhan 430030 China，Wuhan 430030 China |
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| 摘 要： | To investigate the effect of TGF-β1 on the expressions of IL-12, IL-15, IL-18, IL-4 and IL-10 in heart transplantation rejection in rats, a model of rat cervical heterotopic heart transplantation was set up and the model rats were randomly divided into three groups： control group, transplant group and TGF-β1 group. The mRNA expression levels of IL-12, IL-15, IL-18, IL-4 and IL-10 were determined by RT-PCR at the 5th day after the transplantation. The mRNA expression levels of IL- 12, IL-15, IL-18 were increased obviously and those of IL-4, IL-10 were significantly decreased in the transplant group as compared with the control group （P〈0.01）. In the TGF-β1 group, the mRNA ex- pression levels of IL- 12, IL- 15, IL- 18 were significantly decreased and those of IL-4, IL- 10 were significantly increased as compared with the transplant group （P〈0.01）. The immunosuppressive effect of TGF-β1 on heart transplantation rejection was related to its inhibition of the expressions of Th1-type cytokines （IL-12, IL-15, IL-18 etc） and its promotion of the expressions of Th2-tpye cyto- kines （IL-4, IL-10）.
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| 关 键 词： | 心脏移植 器官移植 抗性 TGF-β1 |
| 收稿时间： | 2007-09-09 |
Effect of TGF-β1 on the expression of IL-12, IL-15, IL-18, IL-4 and IL-10 in heart transplantation rejection in rats |
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| Zhao Jinping,Li Ping,Gao Sihai,Wang Xianguo,Gao Xiaojian. Effect of TGF-β1 on the expression of IL-12, IL-15, IL-18, IL-4 and IL-10 in heart transplantation rejection in rats[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2007, 27(6): 643-645. DOI: 10.1007/s11596-007-0605-0 |
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| Authors: | Zhao Jinping Li Ping Gao Sihai Wang Xianguo Gao Xiaojian |
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| Affiliation: | ZHAO Jinping , LI Ping , GAO Sihai , WANG Xianguo , GAO Xiaojian ; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 Department of Cardiac Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 430022. China) |
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| Abstract: | To investigate the effect of TGF-β1 on the expressions of IL-12, IL-15, IL-18, IL-4 and IL-10 in heart transplantation rejection in rats, a model of rat cervical heterotopic heart transplantation was set up and the model rats were randomly divided into three groups: control group, transplant group and TGF-β1 group. The mRNA expression levels of IL-12, IL-15, IL-18, IL-4 and IL-10 were determined by RT-PCR at the 5th day after the transplantation. The mRNA expression levels of IL-12, IL-15, IL-18 were increased obviously and those of IL-4, IL-10 were significantly decreased in the transplant group as compared with the control group (P<0.01). In the TGF-β1 group, the mRNA expression levels of IL-12, IL-15, IL-18 were significantly decreased and those of IL-4, IL-10 were significantly increased as compared with the transplant group (P<0.01). The immunosuppressive effect of TGF-β1 on heart transplantation rejection was related to its inhibition of the expressions of Th1-type cytokines (IL-12, IL-15, IL-18 etc) and its promotion of the expressions of Th2-tpye cytokines (IL-4, IL-10). |
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| Keywords: | heart transplantation TGF-β1 rejection cytokines |
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